Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging.

Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Research Abstract Details 

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Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Abstract Text:

F Wenz,K Rempp,T Hess,J Debus,G Brix,R Engenhart,M V Knopp,G van Kaick,M Wannenmacher,

OBJECTIVE. The purpose of this study was to determine whether it is possible to measure radiation-induced changes in blood volume in low-grade astrocytomas and in normal brain tissue. SUBJECTS AND METHODS. The passage of a bolus of gadopentetate dimeglumine was monitored on a series of 55 T2*-weighted simultaneous dual fast low-angle shot MR images with a standard 1.5-T MR imaging system. Absolute blood volumes were calculated as the area under the tissue concentration-time curve in regions of interest and normalized to the arterial input function. We performed 41 examinations on 19 patients with grade II astrocytomas. For comparison, 13 patients were studied after whole-brain irradiation. RESULTS. A reduction in blood volume (mean +/- SD in milliliters per 100 g) within the tumors from 12.2 +/- 8.7 to 6.5 +/- 5.3 after fractionated conformation radiotherapy was detected, although there was no consistent pattern in different patients. An insignificant reduction was noted in normal gray (9.2 +/- 2.8 to 7.4 +/- 3.2) and white (4.4 +/- 1.9 to 4.1 +/- 2.3) matter outside the target volume. Conversely, we observed a significantly lower blood volume in gray (6.3 +/- 1.2) and white (3.1 +/- 1.0) matter after whole-brain radiotherapy. CONCLUSION. Our results show that a reduction of blood volume in astrocytomas and normal brain tissue after radiotherapy can be quantified by use of dynamic susceptibility contrast MR imaging. Thus, functional monitoring of tumor response and of normal tissue effects becomes possible.

Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Publishing Authors By Initials

F Wenz,K Rempp,T Hess,J Debus,G Brix,R Engenhart,MV Knopp,G van Kaick,M Wannenmacher,

For similar disorders of environmental origin: wounds and injuries: radiation injuries research abstracts see: disorders of environmental origin: wounds and injuries: radiation injuries research

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Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJR. American journal of roentgenology

VOLUME: 166

Page Numbers: 187-93

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Jan

YEAR: 1996

Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Keywords Mesh Terms:

KEYWORDS: Radiation Injuries

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging.

AFFILIATION: Department of Clinical Radiology, University of Heidelberg, Germany.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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