Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults.

Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Research Abstract Details 

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Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Abstract Text:

Robert DiCenzo,Valerie Frerichs,Panupong Larppanichpoonphol,Lisa Predko,Amy Chen,Richard Reichman,Marilyn Morris,

STUDY OBJECTIVES: To determine if quercetin, a bioflavonoid that inhibits p-glycoprotein, alters plasma saquinavir concentrations, and to explore the potential influence on intracellular concentrations. DESIGN: Prospective pharmacokinetic analysis. SETTING: University-affiliated general clinical research center. SUBJECTS: Ten healthy adults (four women, six men) with a mean +/- SD age of 30.7 +/- 9.4 years. INTERVENTION: All subjects received saquinavir 1200 mg 3 times/day with food on days 1-11 and quercetin 500 mg 3 times/day with food on days 4-11. MEASUREMENTS AND MAIN RESULTS: On days 4 and 11, nine blood samples and four peripheral blood mononuclear cell samples were drawn during a steady-state dosing interval. Pharmacokinetic parameters were calculated by using standard noncompartmental techniques. Plasma saquinavir concentrations were similar regardless of quercetin administration. Geometric mean ratios for the area under the concentration-time curve during an 8-hour dosing interval (AUC0-8), maximum concentration in the dosing interval, and minimum concentration in the dosing interval were 0.99 (95% confidence interval [CI] 0.65-1.50), 0.99 (95% CI 0.64-1.54), and 1.06 (95% CI 0.68-1.67), respectively. Intracellular saquinavir concentrations displayed substantial intra- and intersubject variability, which limited the ability to determine the influence of quercetin coadministration (geometric mean ratio for AUC0-8 = 0.51 [95% CI 0.14-1.95], six patients). CONCLUSION: Quercetin coadministration did not influence plasma saquinavir concentrations. Because of substantial inter- and intrasubject variability, more study is necessary to determine if saquinavir intracellular concentrations are altered by coadministration of quercetin.

Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Publishing Authors By Initials

R DiCenzo,V Frerichs,P Larppanichpoonphol,L Predko,A Chen,R Reichman,M Morris,

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Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmacotherapy

VOLUME: 26

Page Numbers: 1255-61

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ISSN: 0277-0008

DAY: 3

MONTH: Sep

YEAR: 2006

Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Information

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LANGUAGE: eng

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AFFILIATION: School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, 14642, USA. robert_dicenzo@urmc.rochester.edu

Country: United States

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MEDLINETA: Pharmacotherapy

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