Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy.

Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Research Abstract Details 

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Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Abstract Text:

Z ,J Simek,

The effect of propylthiouracil (PTU) on the growth activity of intact liver and liver regenerating after partial (65-70%) hepatectomy (PH) was studied in rats. PTU (Propycil, Kali-Chemie, FRG) was dissolved in drinking water (1 g PTU per litre) and this was given to the rats, as their sole source of fluids, three days before PH and then up to the end of the experiment. In rats given PTU, marked inhibition of liver DNA synthesis and the mitotic activity of hepatocytes was found after PH. This effect was potentiated to some extent by partial inanition of the experimental animals given PTU, as demonstrated in a paired feeding test in control rats. PTU inhibition of DNA synthesis in intact and regenerating liver also took effect in thyroidectomized rats, even with substitution (thyroid hormone) therapy. The experiments demonstrated that the effect of propylthiouracil on DNA synthesis in the liver is mediated primarily by way of its direct effect on the liver.

Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Publishing Authors By Initials

Z ,J Simek,

For similar surgical procedures, operative: endocrine surgical procedures: thyroidectomy research abstracts see: surgical procedures, operative: endocrine surgical procedures: thyroidectomy research

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Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 41

Page Numbers: 141-6

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 04

YEAR: 1992

Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Keywords Mesh Terms:

KEYWORDS: Thyroidectomy

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Effect of propylthiouracil on liver regeneration in rats after partial hepatectomy.

AFFILIATION: Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové.

Country: CZECHOSLOVAKIA

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MEDLINETA: Physiol Res

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