Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance.

Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Research Abstract Details 

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Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Abstract Text:

G Cinnella,G Vendemiale,M Dambrosio,G Serviddio,P L Pugliese,G Aspromonte,E Altomare,

We studied the effects of Propofol, Desflurane, and Sevoflurane on the systemic redox balance in patients undergoing laparohysterectomy. We measured blood concentration of glutathione (GSH), plasma antioxidant capacity (Trolox Equivalent Antioxidant Capacity-TEAC), and lipid peroxidation products (malondialdehyde (aMDA) and 4-hydroxynonenal (aHNE) protein adducts). Sixty patients were randomly placed into three groups of twenty people each. In Group P anesthesia was induced with Propofol 2 mg/kg and maintained with 12-10-8 mg/kg/min; in Groups S and D anesthesia was induced with 3 mg/kg Sodium Thiopental and maintained with 2 percent Sevoflurane and 6 percent Desflurane, respectively. Blood samples were collected prior to induction (T0 bas), 60min and 24h postoperatively (T1 60 and T2 24 h). In Group P, GSH increased on T1 60 and returned to baseline on T24h, while TEAC remained unmodified; in Groups S, GSH and TEAC decreased on T1 60 in Group D, on T1 60 there was a slight decrease of GSH and TEAC. The levels of aMDA slightly decreased throughout the study periods in Group P, increased in Group D, and remained stable in Group S. Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Publishing Authors By Initials

G Cinnella,G Vendemiale,M Dambrosio,G Serviddio,PL Pugliese,G Aspromonte,E Altomare,

For similar organic chemicals: phenols: propofol research abstracts see: organic chemicals: phenols: propofol research

PUBMED ID PMID:

MEDLINE DATE: 2007 Jul-Sep

Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: International journal of immunopathology and pharm

VOLUME: 20

Page Numbers: 585-93

Journal Abbreviation:

ISSN: 0394-6320

DAY: 29

MONTH: 11

YEAR: 2007

Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8911335

Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Keywords Mesh Terms:

KEYWORDS: Propofol

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance. Information

Substance Name: desflurane

Registry Number: 57041-67-5

Grant and Affiliation Information for Effect of Propofol, Sevoflurane and Desflurane on systemic redox balance.

AFFILIATION: Institute of Anaesthesiology and Intensive Care, University of Foggia, Foggia, Italy. g.cinnella@unifg.it

Country: Italy

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MEDLINETA: Int J Immunopathol Pharmacol

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