Effect of pravastatin on the development of diabetes and adiponectin production.

Effect of pravastatin on the development of diabetes and adiponectin production. Research Abstract Details 

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Effect of pravastatin on the development of diabetes and adiponectin production. Abstract Text:

Toshiyuki Takagi,Morihiro Matsuda,Manabu Abe,Hironori Kobayashi,Atsunori Fukuhara,Ryutaro Komuro,Shinji Kihara,Muriel J Caslake,Alex McMahon,James Shepherd,Tohru Funahashi,Iichiro Shimomura,Toshiyuki Takagi,Morihiro Matsuda,Manabu Abe,Hironori Kobayashi,Atsunori Fukuhara,Ryutaro Komuro,Shinji Kihara,Muriel J Caslake,Alex McMahon,James Shepherd,Tohru Funahashi,Iichiro Shimomura,

In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus by 30%. However, the mechanism of this effect of pravastatin has not been investigated. In the current study, we examined the effect of pravastatin on the development of diabetes in obese diabetic mice, and on the insulin-induced glucose uptake and adiponectin production. Pravastatin treatment attenuated the development of diabetes in db/db and high fat/high sucrose diet-fed C57BL/6J mice. An in vivo glucose transport assay showed that pravastatin upregulated glucose uptake in adipose tissue. Insulin-stimulated glucose uptake was enhanced in primary adipocytes isolated from pravastatin-treated mice. Pravastatin treatment increased adiponectin production in 3T3-L1 adipocytes. Plasma adiponectin levels were significantly increased in pravastatin-treated mice. Analyses of plasma samples from the WOSCOPS biobank indicated a significant increase of plasma adiponectin levels with pravastatin treatment (placebo -0.28+/-0.34mug/ml versus pravastatin +1.47+/-0.33mug/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment.

Effect of pravastatin on the development of diabetes and adiponectin production. Publishing Authors By Initials

T Takagi,M Matsuda,M Abe,H Kobayashi,A Fukuhara,R Komuro,S Kihara,MJ Caslake,A McMahon,J Shepherd,T Funahashi,I Shimomura,T Takagi,M Matsuda,M Abe,H Kobayashi,A Fukuhara,R Komuro,S Kihara,MJ Caslake,A McMahon,J Shepherd,T Funahashi,I Shimomura,

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Effect of pravastatin on the development of diabetes and adiponectin production. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Atherosclerosis

VOLUME: 196

Page Numbers: 114-21

Journal Abbreviation: Atherosclerosis

ISSN: 1879-1484

DAY: 27

MONTH: 03

YEAR: 2007

Effect of pravastatin on the development of diabetes and adiponectin production. Information

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LANGUAGE: eng

NlmUniqueID: 242543

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AFFILIATION: Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Country: Ireland

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MEDLINETA: Atherosclerosis

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