Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study.

Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Research Abstract Details 

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Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Abstract Text:

BACKGROUND/AIM: Laminin, a major specific non-collagenous glycoprotein of basement membrane, has been proposed as an index of diabetic retinopathy and high serum concentrations have been reported in patients with proliferative diabetic retinopathy. On the other hand, panretinal photocoagulation (PRP) prevents the progression of severe diabetic retinopathy and reverses preretinal neovascularisation. The aim of the study was to investigate the effect of PRP on serum levels of laminin in patients with diabetes. METHODS: 20 patients with diabetes undergoing PRP and 15 patients with mild or moderate non-proliferative diabetic retinopathy in whom a PRP was not performed were included in the study. Serum laminin-P1 (Lam-P1), the largest pepsin resistant fragment of laminin, was determined by radioimmunoassay in each patient before starting PRP and 3 months after it was accomplished. Similarly, a baseline and a 4 month sample were analysed in the non-photocoagulated controls. RESULTS: Serum Lam-P1 concentrations obtained 3 months after PRP were significantly lower when compared with the initial values (1.62 (SD 0.36) U/ml v 1.91 (0.37) U/ml; p <0.001). A decrease of serum levels of Lam-P1 could be seen in all patients. By contrast, in those patients with mild or moderate non-proliferative diabetic retinopathy in whom a PRP was not performed, no significant changes were detected in serum Lam-P1 concentrations (1.72 (0.20) U/ml v 1. 74 (0.17); p=0.250). CONCLUSION: PRP decreases serum Lam-P1 levels in patients with severe diabetic retinopathy. Thus, the studies addressed to evaluate the usefulness of Lam-P1 as a marker of diabetic retinopathy should consider previous PRP as an influencing factor. Finally, our results suggest that retinal source of Lam-P1 strongly contributes to serum Lam-P1 in patients with severe diabetic retinopathy.

Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 83

Page Numbers: 1056-9

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Sep

YEAR: 1999

Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: blood

Chemical & Substance for Abstract: Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study. Information

Substance Name: laminin P1

Registry Number: 0

Grant and Affiliation Information for Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study.

AFFILIATION: Diabetes Unit, Endocrinology Division, Hospital General Vall d'Hebron, Barcelona, Spain.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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