Effect of noise on microvascular integrity in laboratory rats.

Effect of noise on microvascular integrity in laboratory rats. Research Abstract Details 

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Effect of noise on microvascular integrity in laboratory rats. Abstract Text:

Ann L Baldwin,Iris R Bell,

Housing rats in an environment with high personnel activity increases microvascular leakiness to albumin in the mesenteric microcirculation and causes mast cell degranulation. In this study, rats were exposed to daily 15-min episodes of 90-dB SPL noise to determine whether similar effects occurred and whether vitamin E with a-lipoic acid or Traumeel (a homeopathic anti-inflammatory-analgesic) reduced these effects. Groups of rats fed a control diet (1000 IU/kg vitamin E) only, the control diet with Traumeel, or a diet with 10,000 IU/kg vitamin E and 1.65 g/kg lipoic acid were exposed to daily noise for 3 to 5 wk; a fourth group of rats, fed control diet, was housed with no excess noise. The rats were anesthetized, the superior mesenteric artery cannulated, and a portion of the microvasculature perfused for 1 min with fluoroscein isothiocyanate-albumin before fixing for microscopy. All groups exposed to excess noise had significantly more leaks per venule length and greater leak area per venule length than did the quiet group. However, the number and area of leaks in the rats that received Traumeel or vitamin E were significantly smaller than those in rats exposed to noise only. In addition, mast cell degranulation was significantly lower in rats given Traumeel. Thus exposure of rats to excessive noise produces structural damage in the mesenteric microvasculature that is significantly reduced by dietary supplements.

Effect of noise on microvascular integrity in laboratory rats. Publishing Authors By Initials

AL Baldwin,IR Bell,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Effect of noise on microvascular integrity in laboratory rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American Association for Laboratory

VOLUME: 46

Page Numbers: 58-65

Journal Abbreviation: J. Am. Assoc. Lab. Anim. Sci.

ISSN: 1559-6109

DAY: 3

MONTH: Jan

YEAR: 2007

Effect of noise on microvascular integrity in laboratory rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101269489

Effect of noise on microvascular integrity in laboratory rats. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effect of noise on microvascular integrity in laboratory rats. Information

Substance Name: Vitamin E

Registry Number: 1406-18-4

Grant and Affiliation Information for Effect of noise on microvascular integrity in laboratory rats.

AFFILIATION: Department of Physiology, University of Arizona, Tucson, AZ, USA. abaldwin@u.arizona.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR17358

ACRONYM: RR

MEDLINETA: J Am Assoc Lab Anim Sci

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