[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro]

[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro] Research Abstract Details 

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[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro] Abstract Text:

S Deng,Y Hu,

AIM: To study the mechanism of antimalarial action of nitroquine. METHODS: Intraerythrocytic P. yoelii was cultured by the method of Trager and Jensen. The amount of [3H]-ethanolamine incorporation was measured as an index of the phospholipid synthesis. DPH was used as a probe to measure the plasmodial fluorescent polarization. RESULTS: The incorporation of [3H]-ethanolamine into the P. yoelii infected erthrocytes was markedly inhibited by nitroquine. The plasmodial membrane polarization and viscosity were significantly increased by nitroquine. CONCLUSION: Nitroquine could inhibit the phospholipid synthesis and decrease the membrane fluidity of P. yoelii.

[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro] Publishing Authors By Initials

S Deng,Y Hu,

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[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing

VOLUME: 17

Page Numbers: 282-4

Journal Abbreviation: Zhongguo Ji Sheng Chong Xue Yu

ISSN: 1000-7423

DAY: 4

MONTH: 02

YEAR: 1999

[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro] Information

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LANGUAGE: chi

NlmUniqueID: 8709992

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Grant and Affiliation Information for [Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro]

AFFILIATION: Department of Pharmacology, Third Military Medical University, Chongqing 400038.

Country: China

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MEDLINETA: Zhongguo Ji Sheng Chong Xue Yu

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