Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Research Abstract Details 

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Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Abstract Text:

B Eggleston,M Patience,S Edwards,T Adamkiewicz,G R Buchanan,S C Davies,R Dickerhoff,S Donfield,S A Feig,R H Giller,A Haight,J Horan,L L Hsu,N Kamani,P Lane,J E Levine,D Margolis,T B Moore,K Ohene-Frempong,R Redding-Lallinger,I A G Roberts,Z R Rogers,J E Sanders,J P Scott,B Sleight,A A Thompson,K M Sullivan,M C Walters, ,

Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Publishing Authors By Initials

B Eggleston,M Patience,S Edwards,T Adamkiewicz,GR Buchanan,SC Davies,R Dickerhoff,S Donfield,SA Feig,RH Giller,A Haight,J Horan,LL Hsu,N Kamani,P Lane,JE Levine,D Margolis,TB Moore,K Ohene-Frempong,R Redding-Lallinger,IA Roberts,ZR Rogers,JE Sanders,JP Scott,B Sleight,AA Thompson,KM Sullivan,MC Walters, ,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research

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Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: British journal of haematology

VOLUME: 136

Page Numbers: 673-6

Journal Abbreviation: Br. J. Haematol.

ISSN: 0007-1048

DAY: 3

MONTH: Feb

YEAR: 2007

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372544

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Keywords Mesh Terms:

KEYWORDS: Weight Gain

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Information

Substance Name: Hydroxyurea

Registry Number: 127-07-1

Grant and Affiliation Information for Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.

AFFILIATION: Blood and Marrow Transplantation Program, Children's Hospital and Research Center, Oakland, CA 94609, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL 68091

ACRONYM: HL

MEDLINETA: Br J Haematol

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