Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle.

Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Research Abstract Details 

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Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Abstract Text:

Calcineurin, a calcium-regulated protein phosphatase, activates gene expression specific to slow muscle fibers by dephosphorylating a family of the nuclear factor of activated T cells (NFAT), which cooperates with myocyte enhancer factor-2 (MEF2) and AP-1. However, it remains unknown how acute exercise influences this signaling pathway and leads to the development of slow muscle fibers. In the present study, we investigated the effect of moderate acute exercise on mRNA expression of genes in the calcineurin signaling pathway in human skeletal muscle. Five healthy volunteers underwent 1 h bicycle ergometer at 50%VO2max, and vastus lateralis muscle biopsies were collected before and after exercise. Four hours after exercise, alterations in mRNA expression of NFAT 1-3 were observed with a wide variety among subjects, while c-fos mRNA was significantly induced in all subjects. By contrast, the expression of calcineurin, MEF2, and myocyte-enriched calcineurin-interacting protein 1 (MCIP1) remained unchanged. These results suggest that even moderate acute exercise may change mRNA expression of genes in the calcineurin-signaling pathway.

Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: IUBMB life

VOLUME: 55

Page Numbers: 409-13

Journal Abbreviation: IUBMB Life

ISSN: 1521-6543

DAY: 6

MONTH: Jul

YEAR: 2003

Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100888706

Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle. Information

Substance Name: Calcineurin

Registry Number: EC 3.1.3.-

Grant and Affiliation Information for Effect of moderate acute exercise on expression of mRNA involved in the calcineurin signaling pathway in human skeletal muscle.

AFFILIATION: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan. yhitomi@kyorin-u.ac.jp

Country: England

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MEDLINETA: IUBMB Life

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