Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells.

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Abstract Text:

Hajime Yoshisue,Kazuhide Hasegawa,

While epidermal growth factor receptor (EGFR) plays a pivotal role in the repair process of epithelial cells, it is also involved in the overproduction of mucus and goblet cell hyperplasia (GCH), which occurs in chronic airway diseases such as asthma. Among the EGFR ligands, transforming growth factor (TGF)-alpha is thought to be the most important in the synthesis of mucus. Pro-TGF-alpha is cleaved to give an active form by members of the matrix metalloproteinases (MMP)/a disintegrin and metalloproteinases (ADAM) family. Thus MMP/ADAM inhibitors might prevent GCH by inhibiting transactivation of EGFR. Upon stimulation of differentiating normal human bronchial epithelial (NHBE) cells by IL-13, GCH was induced. The mucin genes MUC5AC, MUC5B, and MUC2 were upregulated whereas the expression of ciliated cell markers was greatly repressed. GM6001, a broad-spectrum inhibitor for MMP/ADAM, inhibited IL-13-induced mucin gene expression and mucus production as measured by periodic acid-Schiff staining. This was accompanied by an inhibition of TGF-alpha release. These results suggest that MMP/ADAMs play a pivotal role in the development of GCH in lung epithelial cells.

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Publishing Authors By Initials

H Yoshisue,K Hasegawa,

For similar peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research abstracts see: peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research

PUBMED ID PMID:

MEDLINE DATE:

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 68

Page Numbers: 2024-31

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 0916-8451

DAY: 29

MONTH: Oct

YEAR: 2004

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9205717

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells. Information

Substance Name: Metalloendopeptidases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells.

AFFILIATION: Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Sunto, Shizuoka 411-8731, Japan. hyoshisu@soton.ac.uk

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biosci Biotechnol Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells Related Publications

• An enhanced self-organizing incremental neural network for online unsupervised learning.
• Body mass index reference values (mean and SD) for Japanese children.
• Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
• Central administration of neuromedin U suppresses food intake in chicks.
• Chemokine blockade for lupus model mice.
• Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.
• Distribution of inclusion bodies in tissues from 100 dogs infected with canine distemper virus.
• Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells.
• Effect of prostaglandin E2 on recombinant human bone morphogenetic protein-2-stimulated osteoblastic differentiation in human periodontal ligament cells.
• Extraskeletal osteosarcoma of the jaw.
• Immunostimulatory virotherapy using recombinant Sendai virus as a new cancer therapeutic regimen.
• Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen.
• Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.
• Parkinson's Disease Treatment Guidelines 2002 issued by Societas Neurologica Japonica.
• Participation of endogenous IGF-I and TGF-beta 1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells.
• Phylogenetic relationships of rodent pinworms (genus Syphacia) in Japan inferred from mitochondrial CO1 gene sequences.
• Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
• Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth.
• Progress in SPECT/CT imaging of prostate cancer.
• Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid.
• Recombinant human bone morphogenetic protein-2 stimulates osteoblast differentiation and suppresses matrix metalloproteinase-1 production in human bone cells isolated from mandibulae.
• Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament.
• Role of neutrophils in acute inflammatory liver injury.
• Sensor fusion for taste sensor and odor sensor.
• Single nucleotide polymorphism genotyping of CYP2C19 using a new automated system.
• Sumoylation, a post-translational regulatory process in plants.
• [Detection of FDG-PET and FDG-PET/CT in head and neck squamous cell carcinoma]
• [Homocysteine metabolism]
• [Non-Q wave myocardial infarction (N-QMI)]
• [Subendocardial infarction]