Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica).

Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica). Research Abstract Details 

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Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica). Abstract Text:

Qiang Weng,Erina Saita,Gen Watanabe,Shinji Takahashi,Manila Sedqyar,Akira K Suzuki,Shinji Taneda,Kazuyoshi Taya,Qiang Weng,Erina Saita,Gen Watanabe,Shinji Takahashi,Manila Sedqyar,Akira K Suzuki,Shinji Taneda,Kazuyoshi Taya,Qiang Weng,Erina Saita,Gen Watanabe,Shinji Takahashi,Manila Sedqyar,Akira K Suzuki,Shinji Taneda,Kazuyoshi Taya,

To investigate the effect of hypothyroidism on gonadal and adrenal functions in male Japanese quail (Coturnix japonica), hypothyroidism was induced in male adult Japanese quail by daily administration of 2-Mercapto-1-methylimidazole (methimazole) in their drinking water. Four weeks after methimazole treatment, the Japanese quail were scarificed, and the plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), total T3 (TT3), total T4 (TT4), corticosterone, testosterone, LH and immunoreactive (ir) inhibins were measured by radioimmunoassy, the testes and adrenal glands were removed and weighed and the thyroid glands and testes were fixed in 4% paraformaldehyde for histological observation. The results showed that the hypothyroidism induced by methimazole caused a significant decrease in body and testes weight; the plasma levels of FT3, FT4 and TT4 significantly decreased, and the hypothyroid quail possessed a greater number of small follicles and more follicular epithelial cells in the thyroid gland. In addition, hypothyroidism resulted in a significant decrease in the plasma concentrations of corticosterone, LH, testosterone and ir-inhibin. Furthermore, no spermatogenesis was found in the seminiferous tubules of the methimazole treatment groups. These results clearly demonstrate that hypothyroidism caused both gonadal and adrenal disturbances in the adult male Japanese quail.

Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica). Publishing Authors By Initials

Q Weng,E Saita,G Watanabe,S Takahashi,M Sedqyar,AK Suzuki,S Taneda,K Taya,Q Weng,E Saita,G Watanabe,S Takahashi,M Sedqyar,AK Suzuki,S Taneda,K Taya,Q Weng,E Saita,G Watanabe,S Takahashi,M Sedqyar,AK Suzuki,S Taneda,K Taya,

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Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of reproduction and development

VOLUME: 53

Page Numbers: 1335-41

Journal Abbreviation: J. Reprod. Dev.

ISSN: 0916-8818

DAY: 23

MONTH: 10

YEAR: 2007

Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica). Information

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LANGUAGE: eng

NlmUniqueID: 9438792

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AFFILIATION: College of Biological Science and Technology, Beijing Forestry University.

Country: Japan

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MEDLINETA: J Reprod Dev

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