Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats.

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Abstract Text:

Jyotirmoy Kusari,Sheila Zhou,Edwin Padillo,Kenneth G Clarke,Daniel W Gil,Jyotirmoy Kusari,Sheila Zhou,Edwin Padillo,Kenneth G Clarke,Daniel W Gil,

PURPOSE: To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats. METHODS: Based on basal body weight and blood glucose, Brown Norway (BN) rats were divided into three groups. One group of rats was treated with vehicle (VEH), and the other two groups were treated with 65 mg/kg STZ. After 7 days, VEH-treated rats were treated further with a second VEH, and STZ-treated diabetic rats were treated either with the second VEH or with MEM (10 mg/kg daily) for another 3 to 4 weeks using mini-osmotic pumps. At end of the study, electroretinogram findings, retinal ganglion cell (RGC) count, vitreoretinal vascular endothelial growth factor (VEGF) protein levels, and blood-retinal barrier (BRB) breakdown of the animals were measured. RESULTS: Within 4 to 5 weeks of STZ treatment, the diabetic rats demonstrated significantly less retinal function and fewer RGCs than VEH-treated nondiabetic rats. The diabetic animals also had significantly elevated VEGF protein levels in retina and vitreous fluid and BRB breakdown compared with control nondiabetic rats. Chronic MEM treatment significantly improved retinal function and protected RGC loss in STZ-induced diabetic rats. MEM treatment also significantly decreased elevated vitreoretinal VEGF protein levels and retinal BRB leakage in the diabetic rats. This effect of MEM was not seen in nondiabetic rats. CONCLUSIONS: These results indicate that MEM could be useful for the treatment of ocular diseases, including diabetic retinopathy with neurodegeneration, elevated vitreoretinal VEGF protein levels, and increased BRB breakdown. In addition to the neuroprotective effect of this compound, MEM can reduce vascular changes seen in diabetic retinas. These data are the first to identify the vasculoprotective effect of MEM.

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Publishing Authors By Initials

J Kusari,S Zhou,E Padillo,KG Clarke,DW Gil,J Kusari,S Zhou,E Padillo,KG Clarke,DW Gil,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Investigative ophthalmology & visual science

VOLUME: 48

Page Numbers: 5152-9

Journal Abbreviation: Invest. Ophthalmol. Vis. Sci.

ISSN: 0146-0404

DAY: 26

MONTH: Nov

YEAR: 2007

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7703701

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats.

AFFILIATION: Department of Biological Sciences, Allergan Inc, Irvine, CA 92623-9534, USA. kusari_jyoti@allergan.com

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Invest Ophthalmol Vis Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats Related Publications

• Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression.
• Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome.
• Analysis of the Essential Oil from Helichrysum picardii.
• Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
• Development of a biodegradable bioadhesive containing urethane groups.
• Development of insulin resistance and its relation to diet in the obese child.
• Differences in fine-scale genetic structure and dispersal in Quercus ilex L. and Q. suber L.: consequences for regeneration of mediterranean open woods.
• Differential protein expression of murine macrophages upon interaction with Candida albicans.
• Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats.
• Effectiveness and Safety of Amlodipine in Newly Diagnosed Hypertensive Patients and in Previously Diagnosed Hypertensive Patients not Controlled with their Usual Treatment (NOTA Study).
• Experimental problems in Raman spectroscopy applied to pigment identification in mixtures.
• Extracellular fluid expansion during parenteral refeeding.
• Immobilization of drugs for glaucoma treatment.
• In vitro response to Candida albicans in cultures of whole human blood from young and aged donors.
• Influence of the chemical structure on mobility of PCB congeners in female and male sardine (Sardina pilchardus) from Portuguese coast.
• Oxidized nickel-titanium foams for bone reconstructions: chemical and mechanical characterization.
• Potential microbial risk factors related to soil amendments and irrigation water of potato crops.
• Potential of NMR spectroscopy for the study of human amniotic fluid.
• Proteomic analysis of detergent-resistant membranes from Candida albicans.
• Quantitation of free and glycosidically bound volatiles in and effect of glycosidase addition on three tomato varieties (Solanum lycopersicum L.).
• Reconstructing signal transduction pathways: challenges and opportunities.
• Report. Proteomics Education, an Important Challenge for the Scientific Community: Report on the Activities of the EuPA Education Committee.
• Ten-year trends in self-rated health among spanish adults with diabetes, 1993 2003.
• The Vietnamese Khin population harbors particular N-acetyltransferase 2 allele frequencies.
• The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells.
• The presence of a caregiving relative implicated in the administration of antiretroviral drug administration improves virologic response.
• [Cytoimmunological changes in the bronchoalveolar lavage in asbestos exposure patients]
• [Self-consciousness, consciousness of the other and dementias]
• [Trends in effects of maximum temperatures on organic-cause mortality in Castile-La Mancha, Spain from 1975 to 2003]
• [Utility of amylase serum and urine activity in acute biliary pancreatitis treated with biliary sphincterotomy]