Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori.

Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Research Abstract Details 

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Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Abstract Text:

T Furuta,M Sugimoto,N Shirai,F Matsushita,H Nakajima,J Kumagai,K Senoo,C Kodaira,M Nishino,M Yamade,M Ikuma,H Watanabe,K Umemura,T Ishizaki,A Hishida,T Furuta,M Sugimoto,N Shirai,F Matsushita,H Nakajima,J Kumagai,K Senoo,C Kodaira,M Nishino,M Yamade,M Ikuma,H Watanabe,K Umemura,T Ishizaki,A Hishida,

BACKGROUND: Polymorphism in MDR1 is associated with variation in the plasma level of a proton pump inhibitor. AIM: To investigate whether MDR1 polymorphism is associated with eradication rates of Helicobacter pylori by a triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP2C19 genotype status and bacterial susceptibility to clarithromycin. METHODS: A total of 313 patients infected with H. pylori completed the treatment with lansoprazole 30 mg b.d., clarithromycin 200 mg b.d. and amoxicillin 750 mg b.d. for 1 week. MDR1 C3435T polymorphism and CYP2C19 genotypes of patients and sensitivity of H. pylori to clarithromycin were determined. RESULTS: Logistic regression analysis revealed that the MDR1 polymorphism as well as CYP2C19 genotypes of patients and clarithromycin-resistance of H. pylori were significantly associated with successful eradication. Eradication rates for H. pylori were 82% (83/101: 95% CI = 73-89), 81% (112/139: CI = 73-87), and 67% (44/73: CI = 48-72) in patients with the MDR1 3435 C/C, C/T and T/T genotype, respectively (P = 0.001). CONCLUSIONS: Polymorphism of MDR1 is one of the determinants of successful eradication of H. pylori by the triple therapy with lansoprazole, amoxicillin and clarithromycin, together with CYP2C19 genotype and bacterial susceptibility to clarithromycin.

Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Publishing Authors By Initials

T Furuta,M Sugimoto,N Shirai,F Matsushita,H Nakajima,J Kumagai,K Senoo,C Kodaira,M Nishino,M Yamade,M Ikuma,H Watanabe,K Umemura,T Ishizaki,A Hishida,T Furuta,M Sugimoto,N Shirai,F Matsushita,H Nakajima,J Kumagai,K Senoo,C Kodaira,M Nishino,M Yamade,M Ikuma,H Watanabe,K Umemura,T Ishizaki,A Hishida,

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Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alimentary pharmacology & therapeutics

VOLUME: 26

Page Numbers: 693-703

Journal Abbreviation: Aliment. Pharmacol. Ther.

ISSN: 0269-2813

DAY: 1

MONTH: Sep

YEAR: 2007

Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Information

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LANGUAGE: eng

NlmUniqueID: 8707234

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Grant and Affiliation Information for Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori.

AFFILIATION: Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan. furuta@hama-med.ac.jp

Country: England

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MEDLINETA: Aliment Pharmacol Ther

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