[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro]

[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro] Research Abstract Details 

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[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro] Abstract Text:

Meibian Zhang,Deqiang Lu,Jiliang He,Lifen Jin,

OBJECTIVE: To study that low-intensity microwave whether or not enhances the genotoxic effects of mitomycin C(MMC) on human lymphocytes. METHODS: Single strand DNA breaks and chromosomal aberrations were measured by comet assay and cytokinesis-blocked micronucleus(CBMN) test in vitro when human lymphocytes were exposed to 2,450-MHz microwave (5.0 mW/cm2) alone and in combination with mitomycin C. RESULTS: In the comet assay, the average comet lengths of microwave group[(29.1 +/- 8.1) micron in male and (25.9 +/- 7.5) micron in female] were not significantly different from those of control groups [(26.3 +/- 6.6) and (24.1 +/- 4.3) micron respectively] (P > 0.05). The average comet lengths of MMC group(0.0125, 0.0250, 0.0500, 0.1000 microgram/ml) were significantly longer than those of control groups (P < 0.01) and were increased with the dose of MMC. The average comet lengths of microwave combined with MMC (MW + MMC) also were increased with the doses of MMC and were significantly longer than those of control groups (P < 0.01). When MMC was > or = 0.0250 microgram/ml, microwave and MMC synergistically increased the single strand DNA breaks. In the micronucleus test, the average micronucleus rates of microwave groups were not higher than those of control groups (P > 0.05). The average micronucleus rates of MMC groups and MW + MMC groups were significantly higher than those of control groups (P < 0.01) when MMC was > or = 0.0500 microgram/ml. The average micronucleus rates of MW + MMC groups seemed higher than those of corresponding MMC groups, however the difference was not significant (P > 0.05). CONCLUSION: Low-intensity(2,450-MHz) microwave did not induce DNA and chromosome damages on human lymphocytes, but enhanced the effects of DNA breaks induced by MMC.

[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro] Publishing Authors By Initials

M Zhang,D Lu,J He,L Jin,

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[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 273-6

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Aug

YEAR: 2002

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LANGUAGE: chi

NlmUniqueID: 8410840

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AFFILIATION: Institute of Occupational Health and Environmental Health, School of Medicine, Zhejiang University, Hangzhou 310031, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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