Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors.

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Abstract Text:

Hirotoshi Kikuchi,Masayoshi Yamamoto,Yoshihiro Hiramatsu,Megumi Baba,Manabu Ohta,Kinji Kamiya,Tatsuo Tanaka,Shohachi Suzuki,Haruhiko Sugimura,Masatoshi Kitagawa,Toshikazu Kanai,Yasuhiko Kitayama,Tatsuo Kanda,Ken Nishikura,Hiroyuki Konno,Hirotoshi Kikuchi,Masayoshi Yamamoto,Yoshihiro Hiramatsu,Megumi Baba,Manabu Ohta,Kinji Kamiya,Tatsuo Tanaka,Shohachi Suzuki,Haruhiko Sugimura,Masatoshi Kitagawa,Toshikazu Kanai,Yasuhiko Kitayama,Tatsuo Kanda,Ken Nishikura,Hiroyuki Konno,

The authors have previously reported that loss of heterozygosity (LOH) of the c-kit gene could be responsible for the gain in high proliferative activity in some gastrointestinal stromal tumors (GIST), resulting in enhanced metastatic potential. In the present study, an attempt was made to identify the factors that might predict the postoperative prognosis of patients with metastatic liver GIST. The clinicopathologic or genetic features of resected liver GIST in 14 patients who had undergone a hepatectomy for metachronous liver metastases and who had not received adjuvant imatinib treatment were examined. LOH of the c-kit gene was observed in seven of 12 metastatic liver GIST (58.3%), of which DNA suitable for testing could be extracted. Ten patients had recurrence after hepatectomy and four had none. The median post-recurrent disease-free survival (PRDFS) after hepatectomy was 27.5 months (range 8-104). The tumor-specific PRDFS was examined using clinicopathologic features, c-kit mutation and LOH of the c-kit gene. No single clinicopathologic or genetic finding was significantly associated with PRDFS. However, patients with 'Ki67 labeling index <5% and LOH(-)' had a significantly longer PRDFS than those with 'Ki67 >/=5% or LOH(+)' (P = 0.032), and there was no correlation between the presence of LOH of the c-kit gene and the Ki67 labeling index. LOH of the c-kit gene in metastatic liver seems to be a common event, and LOH of the c-kit gene in resected liver GIST may be a helpful factor in the prediction of the post-recurrent prognosis of patients with liver metastasis.

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Publishing Authors By Initials

H Kikuchi,M Yamamoto,Y Hiramatsu,M Baba,M Ohta,K Kamiya,T Tanaka,S Suzuki,H Sugimura,M Kitagawa,T Kanai,Y Kitayama,T Kanda,K Nishikura,H Konno,H Kikuchi,M Yamamoto,Y Hiramatsu,M Baba,M Ohta,K Kamiya,T Tanaka,S Suzuki,H Sugimura,M Kitagawa,T Kanai,Y Kitayama,T Kanda,K Nishikura,H Konno,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer science

VOLUME: 98

Page Numbers: 1734-9

Journal Abbreviation: Cancer Sci.

ISSN: 1349-7006

DAY: 26

MONTH: Nov

YEAR: 2007

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101168776

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors.

AFFILIATION: Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan. hirotoshi_k@hotmail.com

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors Related Publications

• A comparison of ferritin from normal and tumor-bearing animals.
• A new kinetic property characteristic of the actomyosin-nucleoside-triphosphatase.
• A novel alpha-glucosidase from the moss Scopelophila cataractae.
• An electrophysiological study of pterygopalatine ganglion neurons in the rabbit.
• Anteroventral cochlear nucleus models for considering on the missing fundamental.
• Changes in nasal responsiveness to histamine and to specific antigen after laser surgery.
• Colonic fistula associated with severe acute pancreatitis: Report of two cases.
• Comparison between muscle and liver enolases and their behavior during differentiation and growth.
• Complex formation between regulatory and essential light chain on squid mantle myosin subfragment-1 revealed by thermal denaturation method.
• Crohn's disease-associated colorectal cancer in Japan: report of four cases.
• Discovery of metaflumizone, a novel semicarbazone insecticide.
• Effect of female hormones on the production of IL-4 and IL-13 from peripheral blood mononuclear cells.
• Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors.
• Filament-forming domain of carp dorsal myosin rod.
• G-actin structure revealed by chymotryptic digestion.
• Indocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study.
• Isolation and Hypoglycemic Activity of Moran A, a Glycoprotein of Morus alba Root Barks1.
• Isolation and Hypoglycemie Activity of Oryzarans A, B, C, and D: Glycans of Oryza sativa Roots1.
• Metastasis of renal cell cancer to the ethmoid sinus.
• STUDIES ON THE CONNECTIVE TISSUE. II. NUCLEIC ACIDS AND THE RELATED SUBSTANCES IN THE GRANULOMA INDUCED BY THE AGAR-IMPLANTATION.
• Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy.
• Structure of feruloylhistamine, a hypotensive principle of ephedra roots*.
• The effect of ramatroban (BAY u 3405), a thromboxane A2 receptor antagonist, on nasal cavity volume and minimum cross-sectional area and nasal mucosal hemodynamics after nasal mucosal allergen challenge in patients with perennial allergic rhinitis.
• Thermal stability as a probe of S-1 structure.
• Tonometer pHi monitoring of free jejunal grafts following pharyngolaryngoesophagectomy for hypopharyngeal or cervical esophageal cancer.
• Tonpilz piezoelectric transducers with acoustic matching plates for underwater color image transmission.
• Two calcium regulation systems in squid (Ommastrephes sloani pacificus) muscle. Preparation of calcium-sensitive myosin and troponin-tropomyosin.
• [Hemodynamics and the right ventricular function in exercise loading after radical surgery of tetralogy of Fallot - comparison of the results of various surgical technics]
• [Importance of aortography in ventricular septal defect at the conus arteriosus - with special reference to the radical treatment of VSD and AI]
• [Transposition of great vessels]