Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults.

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Research Abstract Details 

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Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Abstract Text:

BACKGROUND: Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown. OBJECTIVE: The objective was to determine whether lifestyle intervention improves metabolic CHD risk factors in obese older adults. DESIGN: A 6-mo outpatient randomized controlled trial was conducted in obese (BMI >or= 30) older (>or=65 y) adults randomly assigned to diet and exercise therapy (treatment group; n = 17) or no therapy (control group; n = 10). The main outcomes were CHD risk factors. RESULTS: Body weight decreased by 8.4% (8.2 kg) in the treatment group; weight did not change significantly (0.7 kg) in the control group (P < 0.001 between groups). Changes between the control and treatment groups, respectively, in waist circumference (1 and -10 cm), plasma glucose (4 and -4 mg/dL), serum triacylglycerols (0 and -45 mg/dL), and systolic (-2 and -10 mm Hg) and diastolic (0 and -8 mm Hg) blood pressure were different (P < 0.05 for all). The number of subjects with the metabolic syndrome decreased by 59% in the treatment group but did not change significantly in the control group (P < 0.05). Serum free fatty acids increased by 10 micromol/L in the control group and decreased by 99 micromol/L in the treatment group (P < 0.05). Changes between the control and treatment groups, respectively, in C-reactive protein (0.8 and -2.5 mg/L) and interleukin 6 (1.6 and -2.4 pg/mL) were different (P < 0.05 for both). CONCLUSIONS: Lifestyle intervention decreases multiple metabolic CHD risk factors simultaneously in obese older adults.

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Publishing Authors By Initials

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research

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Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of clinical nutrition

VOLUME: 84

Page Numbers: 1317-23

Journal Abbreviation: Am. J. Clin. Nutr.

ISSN: 0002-9165

DAY: 3

MONTH: Dec

YEAR: 2006

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376027

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Keywords Mesh Terms:

KEYWORDS: Weight Loss

MESH TERMS: physiology

Chemical & Substance for Abstract: Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults.

AFFILIATION: Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA. dvillare@im.wustl.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR016191

ACRONYM: RR

MEDLINETA: Am J Clin Nutr

REFSOURCE: Am J Clin Nutr. 2006 Dec;84(6):1257-8

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