Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate.

Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate. Research Abstract Details 

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Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate. Abstract Text:

G Francois,M Blanc,A Calderon,F Rose,

It has been shown that ketoisocaproate (KIC) spares nitrogen (N) in fasting postoperative patients while leucine does not. The aim of the present study was to determine if KIC when compared with leucine, decreases nitrogen excretion in postoperative patients receiving energy substrate. Thirty patients undergoing gynecological surgery (hysterectomy with or without lymphadenectomy) were randomized to receive for the first 3 postoperative days one of the following I.V. solutions per kilo and per day: 3 g glucose (group A) 3 g glucose + 90 mg Leucine (group B), 3 g glucose + 100 mg ketoleucine (group C). The output of 3 methylhistidine (3 MEH), total nitrogen and creatinine were measured daily. Although muscle protein breakdown measured as 3 MEH/creatinine molar ratio was significantly reduced in group C as compared with A and B, total nitrogen and creatinine did not differ significantly in A, B and C. Thus, the metabolic effects of KIC in postoperative patients are appreciably influenced by glucose infusions and the usefulness of KIC infusions in such patients needs further study.

Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate. Publishing Authors By Initials

G Francois,M Blanc,A Calderon,F Rose,

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Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 3

Page Numbers: 99-101

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ISSN: 0261-5614

DAY: 10

MONTH: Jul

YEAR: 1984

Effect of leucine or ketoleucine on nitrogen metabolism in postoperative patients receiving energy substrate. Information

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LANGUAGE: eng

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AFFILIATION: Department of Anesthesiology and Intensive Care G.H.R. La Timone 13385 Marseille Cedex 4 France.

Country: England

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MEDLINETA: Clin Nutr

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