Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds.

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Abstract Text:

Kyungsup Shin,Ambalangodage C Jayasuriya,David H Kohn,Kyungsup Shin,Ambalangodage C Jayasuriya,David H Kohn,

A biomimetic approach involving the self-assembly of mineral within the pores of three-dimensional porous polymer scaffolds is a promising strategy to integrate advantages of inorganic and organic phases into a single material for hard tissue engineering. Such a material enhances the ability of progenitor cells to differentiate down an osteoblast lineage in vitro and in vivo, compared with polymer scaffolds. The mechanisms regulating mineral formation in this one-step process, however, are poorly understood, especially the effects of ionic activity products (IP) of the mineralizing solution and incubation time. The aims of this study were to define the structure and composition of mineral formed within the pores of biodegradable polymer scaffolds as a function of IP and time. Three-dimensional poly(lactide-co-glycolide) scaffolds were fabricated by solvent casting/particulate leaching and incubated for 4-16 days in six variants of simulated body fluid whose IPs were varied by adjusting ionic concentrations. Scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy demonstrated the formation of carbonated apatite with sub-micrometer sized crystals that grew into spherical globules extending out of the scaffold pore surfaces. As IP increased, more mineral grew on the scaffold pore surfaces, but the apatite became less crystalline and the Ca/P molar ratio decreased from 1.63 +/- 0.005 to 1.51 +/- 0.002. Since morphology, composition, and structure of mineral are factors that affect cell function, this study demonstrates that the IP of the mineralizing solution is an important modulator of material properties, potentially leading to enhanced control of cell function. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Publishing Authors By Initials

K Shin,AC Jayasuriya,DH Kohn,K Shin,AC Jayasuriya,DH Kohn,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part A

VOLUME: 83

Page Numbers: 1076-86

Journal Abbreviation:

ISSN: 1549-3296

DAY: 15

MONTH: Dec

YEAR: 2007

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds.

AFFILIATION: Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109-2099.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biomed Mater Res A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional polylactide-co-glycolide scaffolds Related Publications

• A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer.
• BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
• Constitution and quantity of lysis buffer alters outcome of reverse phase protein microarrays.
• Control of upright stance over inclined surfaces.
• Effect of a transition diet on production performance and metabolism in periparturient dairy cows.
• Effect of ionic activity products on the structure and composition of mineral self assembled on three-dimensional poly(lactide-co-glycolide) scaffolds.
• Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
• Electrospun mat of tyrosine-derived polycarbonate fibers for potential use as tissue scaffolding material.
• Encephalopathy following pertussis vaccine prophylaxis.
• Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific.
• Further studies on use of streptomycin in treatment of whooping cough.
• Genetic therapies against HIV.
• H-reflex depression simulated by a biologically realistic motoneuron network.
• HAUSP-regulated switch from auto- to p53 ubiquitination by Mdm2 (in silico discovery).
• Host-Synthesized Secondary Compounds Influence the In Vitro Interactions between Fungal Endophytes of Maize.
• Isolated avulsion of the biceps femoris insertion-injury patterns and treatment options: a case report and literature review.
• Letters to the Editor.
• Mechanical factors in cardiac rupture.
• Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report.
• Psychopathology and other health dimensions among the offspring of Holocaust survivors: results from the Israel National Health Survey.
• Radiation-induced changes on beef fat-cephalin mixtures by gamma-radiation. Inhibition of cis-trans isomerization.
• Studies of self-incompatibility in wild tomatoes: I. S-allele diversity in Solanum chilense (Dun.) Reiche (Solanaceae).
• Studies of self-incompatibility in wild tomatoes: I. S-allele diversity in Solanum chilense Dun. (Solanaceae).
• Substrate mineralization stimulates focal adhesion contact redistribution and cell motility of bone marrow stromal cells.
• The public mental health significance of research on socio-economic factors in schizophrenia and major depression.
• Treatment of pertussis with polymyxin B (aerosporin).
• Uniform deposition of protein incorporated mineral layer on three-dimensional porous polymer scaffolds.
• Viscoelastic properties of fibrinogen adsorbed to the surface of biomaterials used in blood-contacting medical devices.
• [Not Available.]
• [Soft tissue balancing in valgus gonarthrosis]