Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles.

Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Research Abstract Details 

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Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Abstract Text:

Mareomi Hamada,Jun Aono,Shuntaro Ikeda,Kouki Watanabe,Shinji Inaba,Jun Suzuki,Tomoaki Ohtsuka,Yuji Shigematsu,Mareomi Hamada,Jun Aono,Shuntaro Ikeda,Kouki Watanabe,Shinji Inaba,Jun Suzuki,Tomoaki Ohtsuka,Yuji Shigematsu,

BACKGROUND: Cibenzoline is able to improve left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), but the exact mechanism remains to be determined. METHODS AND RESULTS: The present study was designed to elucidate the effect of intravenous administration of 1.4 mg/kg of cibenzoline on aortic and LV pressures, and transmitral Doppler flow pattern in 7 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with hypertrophic nonobstructive cardiomyopathy (HNCM). Before and at the end of the administration, aortic and LV pressures, LV pressure gradient (LVPG) and transmitral Doppler velocity profiles were examined. After the administration of cibenzoline, LV minimal and end-diastolic pressures decreased from 9+/-4 mmHg to 1+/-5 mmHg (p=0.0049) and from 22+/-7 mmHg to 14+/-5 mmHg (p=0.0106) in patients with HOCM, and from 9+/-5 mmHg to 5+/-3 mmHg (p=0.0036) and from 20+/-6 mmHg to 14+/-3 mmHg (p=0.0033) in patients with HNCM. LVPG decreased in all patients with HOCM. E-wave velocity increased, A-wave velocity decreased, and thus the E/A ratio increased from 0.77+/-0.29 to 1.20+/-0.48 (p=0.0004). CONCLUSIONS: Reduction of LV diastolic pressures by intravenous administration of cibenzoline may be related to an improvement in the E/A ratio in patients with HCM.

Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Publishing Authors By Initials

M Hamada,J Aono,S Ikeda,K Watanabe,S Inaba,J Suzuki,T Ohtsuka,Y Shigematsu,M Hamada,J Aono,S Ikeda,K Watanabe,S Inaba,J Suzuki,T Ohtsuka,Y Shigematsu,

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Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1540-4

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Oct

YEAR: 2007

Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles. Keywords Mesh Terms:

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Grant and Affiliation Information for Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles.

AFFILIATION: Division of Cardiology, Uwajima City Hospital, Uwajima, Japan. mhamada@uwajima-mh.go.jp

Country: Japan

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MEDLINETA: Circ J

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