Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats.

Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats. Research Abstract Details 

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Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats. Abstract Text:

M Vallgren,K G Tranberg,S Vallgren,H S Bjornson,J E Fischer,

Although infusion of Intralipid((R)) has been reported to block reticuloendothelial system (RES) function, it is unclear if this is true at rates used clinically. This study investigates the effect of Intralipid((R)), infused at a rate providing about half of the non-protein caloric needs, on survival and bacterial clearance in septic rats. Continuous infusion of Intralipid((R)) (0.9 g/100 g bw/d) or saline (controls) was started immediately after induction of hyperdynamic intra-abdominal sepsis (bacterial agents: E. coli, B. thetaiotamicron). RES function was studied by means of intravenous injection of Selenium-labelled, viable E. coli after 24 or 48 h. Compared to the saline-treated controls, Intralipid((R)) did not cause any change in clearance from blood or localisation to liver, spleen or lungs. The 24 and 48 h survival rates were about 80 and 65%, respectively, and similar in the two groups. It is concluded that infusion of Intralipid((R)) at a rate close to that used clinically did not impair survival or bacterial clearance in rats with gram-negative sepsis.

Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats. Publishing Authors By Initials

M Vallgren,KG Tranberg,S Vallgren,HS Bjornson,JE Fischer,

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Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 5

Page Numbers: 67-71

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ISSN: 0261-5614

DAY: 11

MONTH: Feb

YEAR: 1986

Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats.

AFFILIATION: Department of Surgery, University of Lund, Sweden; University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A.

Country: England

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MEDLINETA: Clin Nutr

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