Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine.

Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Research Abstract Details 

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Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Abstract Text:

The effect of intravenous atropine (2.0 mg/70 kg) and intragastric bile salts (5.0-5.5 mM) on ionic fluxes across the gastric mucosa was studied. Serial instillations of bile salts, in 200 ml 160 m-equiv/l HCl with (51)Cr as a non-absorbable indicator, were performed in eight normal subjects. Five subjects received a bile salt mixture of 84% taurocholic acid, 14% taurodeoxycholic acid, and 2% taurochenodeoxycholic acid. With HCl alone (controls) the mean net flux into the lumen was 1.4 m-equiv H(+), 2.9 m-equiv Cl(-), 1.5 m-equiv Na(+), and 0.26 m-equiv K(+) per 15 minutes after the first instillation. Where atropine plus bile salt was given the loss from the lumen was 5.4 m-equiv H(+) (p < 0.01) and 1.9 m-equiv Cl(-) (p < 0.05) and movement into the lumen was 3.2 m-equiv Na(+) (p < 0.01) and 0.20 m-equiv K(+) in the corresponding period. Similar but smaller ion flux changes occurred in three subjects who received atropine and pure taurodeoxycholic acid. The net loss of H(+) from the gastric lumen was greater after atropine-bile salts than that shown in previous studies with bile salts alone. It is postulated that atropine reduced the volume of endogenous HCl secretion unmasking the loss of H(+).

Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Publishing Authors By Initials

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Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gut

VOLUME: 12

Page Numbers: 257-61

Journal Abbreviation: Gut

ISSN: 0017-5749

DAY: 4

MONTH: Apr

YEAR: 1971

Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Information

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LANGUAGE: eng

NlmUniqueID: 2985108

Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine. Information

Substance Name: Sodium

Registry Number: 7440-23-5

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