Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice.

Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Research Abstract Details 

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Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Abstract Text:

Kouji Nagata,Kouji Masumoto,Toru Uesugi,Shinya Yamamoto,Keigo Yoshizaki,Satoshi Fukumoto,Kazuaki Nonaka,Tomoaki Taguchi,Kouji Nagata,Kouji Masumoto,Toru Uesugi,Shinya Yamamoto,Keigo Yoshizaki,Satoshi Fukumoto,Kazuaki Nonaka,Tomoaki Taguchi,

In congenital diaphragmatic hernia (CDH), both mortality and morbidity are mainly caused by pulmonary hypoplasia and persistent pulmonary hypertension. Insulin-like growth factors (IGFs) are one of the growth factors that may play an important role in the fetal lung development. Elucidating the roles of these growth factors regarding fetal lung development would thus provide new insight regarding the optimal therapy for CDH patients. The aim of this study is to investigate the role of IGFs in the fetal lung development. The mRNA expression of IGFs and its receptors was analyzed by real-time RT-PCR from embryonic day (E) 11.5 to E18.5 mice. In addition, the lungs dissected from the E17.5 mice were divided into the following three groups; lungs cultured only in the serum-free medium (group I n = 5), lungs cultured in medium containing either IGF-I (group II n = 5), or IGF-II (group III n = 5). All cultures were investigated by immunohistochemistry, using the antibodies of thyroid transcription factor (TTF)-1, prosurfactant protein (proSp)-C, alpha smooth muscle actin (alpha-SMA), and anti-proliferating cell nuclear antigen (PCNA). The mRNA expression level of both IGF-I and IGF-II was higher during the earlier stage than that of later stage. In contrast, the mRNA expression of both IGF-I receptor (IGF-IR) and IGF-II receptor (IGF-IIR) was higher from the E17.5 to E18.5 than that at any other stage. The number of positive cells for TTF-1, proSp-C, alpha-SMA and PCNA increased more in both groups II and III than in group I. Based on our findings, IGFs are suggested to induce alveolar and vascular maturation in the late stages of fetal lung development. Therefore, the administration of IGFs to the fetal CDH lung may thus be able to effectively improve the symptoms of hypoplastic lung.

Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Publishing Authors By Initials

K Nagata,K Masumoto,T Uesugi,S Yamamoto,K Yoshizaki,S Fukumoto,K Nonaka,T Taguchi,K Nagata,K Masumoto,T Uesugi,S Yamamoto,K Yoshizaki,S Fukumoto,K Nonaka,T Taguchi,

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Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric surgery international

VOLUME: 23

Page Numbers: 953-9

Journal Abbreviation: Pediatr. Surg. Int.

ISSN: 0179-0358

DAY: 18

MONTH: Oct

YEAR: 2007

Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Information

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LANGUAGE: eng

NlmUniqueID: 8609169

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Grant and Affiliation Information for Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice.

AFFILIATION: Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Country: Germany

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MEDLINETA: Pediatr Surg Int

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