Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children.

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Abstract Text:

Alexander R Santos,Sabrina M Heidemann,Henry L Walters,Ralph E Delius,Alexander R Santos,Sabrina M Heidemann,Henry L Walters,Ralph E Delius,

OBJECTIVE: To determine whether inhaled steroid administration after cardiopulmonary bypass will attenuate pulmonary inflammation and improve lung compliance and oxygenation. DESIGN: Randomized, prospective, double-blind, placebo-controlled clinical trial. SETTING: Children's Hospital of Michigan, intensive care unit. PATIENTS: Thirty-two children <2 yrs of age with congenital heart disease requiring cardiopulmonary bypass. INTERVENTIONS: Participants were randomly assigned to one of two groups. Group 1 (n = 16) received an inhaled steroid, Budesonide (0.25 mg/2 mL), and group 2 (n = 16) received an inhaled placebo (2 mL of inhaled 0.9% saline). The nebulizations were given at the end of cardiopulmonary bypass, 6 hrs after cardiopulmonary bypass, and 12 hrs after cardiopulmonary bypass. Two hours after each nebulization, bronchoalveolar lavage for interleukin-6 and interleukin-8 was collected. MEASUREMENTS AND MAIN RESULTS: The concentrations of interleukin-6 and interleukin-8 in the bronchoalveolar lavage increased in both groups after cardiopulmonary bypass. Interleukin-6 peaked 2 hrs after cardiopulmonary bypass and was decreasing by 14 hrs after cardiopulmonary bypass. However, administration of corticosteroid did not affect the production of interleukin-6 when compared with the placebo group (378 +/- 728 vs. 287 +/- 583 pg/mL pre-cardiopulmonary bypass, 1662 +/- 1410 vs. 1584 +/- 1645 pg/mL at the end of cardiopulmonary bypass, 2601 +/- 3132 vs. 3677 +/- 4935 pg/mL 2 hrs after cardiopulmonary bypass, and 1792 +/- 3100 vs. 1283 +/- 1344 pg/mL 14 hrs after cardiopulmonary bypass; p > .05). Likewise, interleukin-8 in the lavage fluid was similar in both the placebo and steroid groups at all time points (570 +/- 764 vs. 990 +/- 1147 pg/mL pre-cardiopulmonary bypass, 1647 +/- 1232 vs. 1394 +/- 1079 pg/mL at the end of cardiopulmonary bypass, 1581 +/- 802 vs. 1523 +/- 852 pg/mL 2 hrs after cardiopulmonary bypass, and 1652 +/- 1069 pg/mL vs. 1808 +/- 281 pg/mL 14 hrs after cardiopulmonary bypass; p > .05). Lung compliance and oxygenation were similar in both groups. CONCLUSIONS: Cardiopulmonary bypass is associated with a pulmonary inflammatory response. Inhaled corticosteroid did not affect the pulmonary inflammatory response as measured by interleukin-6 and interleukin-8 concentrations in the lung lavage after cardiopulmonary bypass. Pulmonary mechanics and oxygenation were not improved by the use of inhaled corticosteroid.

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Publishing Authors By Initials

AR Santos,SM Heidemann,HL Walters,RE Delius,AR Santos,SM Heidemann,HL Walters,RE Delius,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric critical care medicine : a journal of th

VOLUME: 8

Page Numbers: 465-9

Journal Abbreviation:

ISSN: 1529-7535

DAY: 24

MONTH: Sep

YEAR: 2007

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100954653

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children.

AFFILIATION: Department of Pediatrics, Wayne State University, Detroit, MI, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Crit Care Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children Related Publications

• Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children.
• Neural substrates of vocalizations in gulls and pigeons.
• Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon.
• Single-stage versus 2-stage repair of coarctation of the aorta with ventricular septal defect.
• Surgical vs. percutaneous atrial septal defect closure: Remote effects on left ventricular diastolic function.
• Technique of single-stage repair of coarctation of the aorta with ventricular septal defect.
• The mechanically stable steam sterilization of bone grafts.
• Visual evoked potentials in the forebrain of the pigeon.
• [Functional peripheral vascular disorders.]
• [Not Available.]