Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice.

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Abstract Text:

M Keshavarzi,Z M Hassan,

In this study, a crude leishmanial antigen, was prepared by son icating Leishmania major promastigotes used to induce immunity in BALB/c mice against cutaneous leishmaniasis. Correlation between the route of antigen injection and the efficacy of induced protection was examined. To enhance the effectiveness of the antigen, an irnmunostimulant drug, daraprim (pyrimethamine), was administered simultaneously with the antigen. The experiment demonstrated that simultaneous intraperitoneal injection of the antigen and daraprim resulted in protection from subsequent development of cutaneous lesions. Results of lymphocyte proliferation from mice immunized with either the antigen or antigen-daraprim mixture showed a signficant response to the antigen. The results suggest that daraprim can be used in prophylaxis programs to enhance the effectiveness of vaccines for cutaneous leishmaniasis.

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Publishing Authors By Initials

M Keshavarzi,ZM Hassan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Iranian journal of allergy, asthma, and immunology

VOLUME: 2

Page Numbers: 7-12

Journal Abbreviation:

ISSN: 1735-1502

DAY: 15

MONTH: Mar

YEAR: 2003

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101146178

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice.

AFFILIATION: Department of Parasitology, School of Medical Sciences, University of Tarbiat Modarres, Iran.

Country: Iran

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Iran J Allergy Asthma Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice Related Publications

• A prescription for improving national health care.
• A quintuple therapy for H. pylori eradication.
• Amino acid side chain interactions in the presence of salts.
• CXCL10/IP-10: A missing link between inflammation and anti-angiogenesis in preeclampsia?
• Clinical significance of the presence of amniotic fluid 'sludge' in asymptomatic patients at high risk for spontaneous preterm delivery.
• Constituents of Persicaria stagnina.
• Culture and mental health of women in South-East Asia.
• Delayed presentation of penetrating craniocerebral injury caused by a nail.
• Development of a multiplex real-time PCR assay using SYBR Green 1 chemistry for simultaneous detection and subtyping of H9N2 influenza virus type A.
• Dietary mutagen exposure and risk of pancreatic cancer.
• Effect of immunomodulator daraprim on potentiation of vaccine protection of leishmania major in BALB/c mice.
• Effect of juvenile hormone and ecdysone on initiating blood meal--dependent vitellogenic ovarian cycles in autogenous and anautogenous Culex pipiens (Diptera : Culicidae).
• Emergency medicine in the UK: the future is bright!
• External cephalic version for breech presentation at term.
• FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s).
• Letter to the editor.
• Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy.
• OC144: Clinical significance of the presence of amniotic fluid 'sludge' in patients with cervical cerclage.
• OP12.09: The value of the sagittal view of the 'ductal arch plane' in the prenatal diagnosis and counseling of conotruncal anomalies using 4D ultrasonography.
• Reverse transcriptase-polymerase chain reaction-enzyme linked immunosorbent assay for rapid detection of avian influenza virus subtype H9N2.
• Room temperature sphere-to-rod growth and gelation of PEO-PPO-PEO triblock copolymers in aqueous salt solutions.
• Stroke: Incidence and pattern in Benghazi, Libya.
• Structural variability of the carboxy-terminus of Epstein-Barr virus encoded latent membrane protein 1 gene in Hodgkin's lymphomas.
• Systemic lupus erythematosus presenting as massive ascites and pancreatitis.
• The prognostic role of donor corneoscleral rim cultures in corneal transplantation.
• The role of the sagittal view of the ductal arch in identification of fetuses with conotruncal anomalies using 4-dimensional ultrasonography.
• The simultaneous assay of emetine and cephaeline in ipecacuanha and its preparations by spectrofluorimetry.
• Transvaginal sonographic measurement of cervical length vs. Bishop score in labor induction at term: tolerability and prediction of Cesarean delivery.
• Treatment of anterolateral impingements of the ankle joint by arthroscopy.
• Ultrafiltered milk reduces bitterness in reduced-fat Cheddar cheese made with an exopolysaccharide-producing culture.