Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint.

Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint. Research Abstract Details 

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Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint. Abstract Text:

I Tojyo,A Yamaguchi,T Nitta,H Yoshida,S Fujita,T Yoshida,I Tojyo,A Yamaguchi,T Nitta,H Yoshida,S Fujita,T Yoshida,

Objective: The expression of tenascin-C in the synovial membrane of the internal derangement (ID) of the temporomandibular joint (TMJ) has been reported. Hypoxia of the synovial membrane in TMJ is considered to be a cause for the pathophysiology of ID. In this study, we clarify the contribution of hypoxia and interleukin-1beta in the expression of tenascin-C in ID of TMJ. Materials and methods: Synovial fibroblasts and disk cells obtained from ID of TMJs were cultured and treated with interleukin-1beta under normoxia and hypoxia. A Western blot analysis and reverse transcription-polymerase chain reaction analysis were used to identify tenascin-C in cultured synovial fibroblasts and disk cells. In addition, the immunohistochemical staining of tenascin-C was carried out for the specimens of ID of TMJs and normal. Results: The combination of hypoxia and interleukin-1beta caused a significant increase in tenascin-C protein and mRNA of synovial fibroblasts. In contrast, the combination caused no increase in tenascin-C in disk cells. However, the immunohistochemical staining demonstrated tenascin-C to be significantly detected in both the synovial tissue and disks in ID of TMJ. Conclusions: These results indicate that hypoxic conditions with inflammation modulate the tenascin-C expression in synovial fibroblasts, but not in disk cells.

Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint. Publishing Authors By Initials

I Tojyo,A Yamaguchi,T Nitta,H Yoshida,S Fujita,T Yoshida,I Tojyo,A Yamaguchi,T Nitta,H Yoshida,S Fujita,T Yoshida,

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Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oral diseases

VOLUME: 14

Page Numbers: 45-50

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ISSN: 1354-523X

DAY: 4

MONTH: Jan

YEAR: 2008

Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint.

AFFILIATION: Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Wakayama, Japan.

Country: Denmark

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MEDLINETA: Oral Dis

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