Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.

Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Research Abstract Details 

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Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Abstract Text:

B N Rama,K N Prasad,

The effect of heat in combination with DL-alpha-tocopheryl (vitamin E) succinate and adenosine 3', 5'-cyclic monophosphate (cAMP) stimulating agents on mouse neuroblastoma cells ( NBP2 ) in culture on the criterion of growth inhibition (due to cell death and inhibition of cell division) was studied. Heat (41 degrees-40 degrees) alone inhibited growth; however, the extent of growth inhibition was dependent upon the temperature and the time of heat treatment. Heat (41 degrees-40 degrees) in combination with vitamin E succinate (5 micrograms/ml) produced an additive effect on the criterion of growth inhibition. Vitamin C (100 micrograms/ml) failed to modify the effect of heat. Prostaglandin A2, a stimulator of adenylate cyclase, and 4 - (3-butoxy-4-methoxybenzyl)-2-imidazolidinone ( R020 -1724), an inhibitor of cyclic nucleotide phosphodiesterase, are known to induce irreversible differentiation in mouse neuroblastoma cells in culture. These agents, in combination with heat (40 degrees) produced a synergistic effect on the criterion of growth inhibition. These data suggest that the addition of vitamin E and cAMP stimulating agents may increase the effectiveness of hyperthermia protocol.

Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Publishing Authors By Initials

BN Rama,KN Prasad,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Life sciences

VOLUME: 34

Page Numbers: 2089-97

Journal Abbreviation: Life Sci.

ISSN: 0024-3205

DAY: 21

MONTH: May

YEAR: 1984

Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Information

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LANGUAGE: eng

NlmUniqueID: 375521

Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Information

Substance Name: Cyclic AMP

Registry Number: 60-92-4

Grant and Affiliation Information for Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.

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Country: ENGLAND

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MEDLINETA: Life Sci

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