[Effect of high level spinal cord injury on rat heart function.]

[Effect of high level spinal cord injury on rat heart function.] Research Abstract Details 

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[Effect of high level spinal cord injury on rat heart function.] Abstract Text:

Zhen-dong Xu,Xue-yin Shi,Xing-ying He,Gang Liu,Tian-wen Ye,

OBJECTIVE: To study the effects of high level spinal cord injury (SCI) on rat heart, and investigate the role of endothelin-1 (ET-1) in the harmful effects on heart after SCI. METHODS: Forty-eight male SD rats were randomly divided into six groups of 8 animals each: control group; 4-hour group: 4 th hour after injury to spinal cord at cervical 7 level; 12-hour group: 12 th hour after injury to 7 spinal cord at C7 level; 24-hour group with same injury; 48-hour group and 72-hour group, all with same injury. Mean arterial pressure (MAP), heart rate (HR), left ventricle systolic pressure (LVSP), and left ventricular maximum velocities of contraction (+/-dp/dt max) were recorded in each group. Lactate dehydrogenase (LDH), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB) and ET-1 contents in the myocardium. were also measured. Specimens of the myocardium were harvested for ultrastructure examination with transmission electron microscopy. RESULTS: Hemodynamics variables including HR, MAP, LVSP and+/-dp/dtmax were significantly decreased in all the injury groups compared with that of control group (P<0.05 or P<0.01). These variables in 12-hour group showed lowest values among all the groups (all P<0.01). But the values of cardiac enzymes were much higher in five injury groups compared with that of control group (P<0.05 or P<0.01). ET-1 contents in serum and cardiac tissue raised markedly after the injury was inflicted to the animals (P<0.05), reaching peak at 12 hours (P<0.01). Ultrastructural examination of the myocardial tissue demonstrated that there were mild dissolution of myocardial fibriles and vacuolation of mitochondria at 12 hours after injury. CONCLUSION: High level SCI could induce myocardial injuries and an excessive production of ET-1 in circulation and myocardial tissue might play a role in myocardial damage after injury of the spinal cord at a high level.

[Effect of high level spinal cord injury on rat heart function.] Publishing Authors By Initials

ZD Xu,XY Shi,XY He,G Liu,TW Ye,

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[Effect of high level spinal cord injury on rat heart function.] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 17

Page Numbers: 57-9

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ISSN: 1003-0603

DAY: 7

MONTH: Jan

YEAR: 2005

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LANGUAGE: chi

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AFFILIATION: Department of Anesthesiology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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