Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study.

Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Research Abstract Details 

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Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Abstract Text:

Marjorie Letitia Hubbard,Wenjun Ying,Craig S Henriquez,Marjorie Letitia Hubbard,Wenjun Ying,Craig S Henriquez,Marjorie Letitia Hubbard,Wenjun Ying,Craig S Henriquez,

Aims To use microstructural computer models to study how four features of myocardial architecture affect propagation: brick wall tissue structures, jutting at cell ends, gap junction distribution and conductance along cell borders, and increased structural discontinuity. Methods and results Simulations of longitudinal and transverse plane wave propagation and point propagation were performed in several two-dimensional (2D) microstructural models of adult cardiac tissue. Conduction velocities and maximum upstroke velocities were measured for a range of gap junction conductances and distributions. In tissue models with normal to low connectivity, brick wall architecture and jutting decrease cell-to-cell delay, increase longitudinal conduction velocity, and decrease longitudinal maximum upstroke velocity. Transverse conduction velocity also increases if the overlap or jutting introduces additional lateral (side-to-side) connections between myocytes. Both end-to-end and side-to-side interplicate gap junctions increase longitudinal and transverse conduction velocity; however, side-to-side interplicate gap junctions have the greatest influence on transverse conduction velocity and longitudinal and transverse maximum upstroke velocity. Conclusion The complex structure of myocardium creates additional pathways of current flow that enhance both longitudinal and transverse propagation. These alternative pathways of current help to maintain conduction as connectivity between cells decreases.

Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Publishing Authors By Initials

ML Hubbard,W Ying,CS Henriquez,ML Hubbard,W Ying,CS Henriquez,ML Hubbard,W Ying,CS Henriquez,

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Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Europace : European pacing, arrhythmias, and cardi

VOLUME: 9 Suppl 6

Page Numbers: vi20-vi28

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ISSN: 1099-5129

DAY: 25

MONTH: Nov

YEAR: 2007

Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study.

AFFILIATION: Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Durham, NC 27708, USA.

Country: England

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