Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging.

Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Research Abstract Details 

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Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Abstract Text:

J A Maldjian,

BACKGROUND AND PURPOSE: Functional connectivity MR (fcMR) imaging is used to map regions of brain with synchronous, regional, slow fluctuations in cerebral blood flow. We tested the hypothesis that focal cerebral lesions do not eradicate expected functional connectivity. METHODS: Functional MR (fMR) and fcMR maps were acquired for 12 patients with focal cerebral tumors, cysts, arteriovenous malformations, or in one case, agenesis of the corpus callosum. Task activation secondary to text listening, finger tapping, and word generation was mapped by use of fMR imaging. Functional connectivity was measured by selecting "seed" voxels in brain regions showing activation (based on the fMR data) and cross correlating with every other voxel (based on data acquired while the subject performed no task). Concurrence of the fMR and fcMR maps was measured by comparing the location and number of voxels selected by both methods. RESULTS: Technically adequate fMR and fcMR maps were obtained for all patients. In patients with focal lesions, the fMR and fcMR maps correlated closely. The fcMR map generated for the patient with agenesis of the corpus callosum failed to reveal functional connectivity between blood flow in the left and right sensorimotor cortices and in the frontal lobe language regions. Nonetheless, synchrony between blood flow in the auditory cortices was preserved. On average, there was 40% concurrence between all fMR and fcMR maps. CONCLUSION: Patterns of functional connectivity remain intact in patients with focal cerebral lesions. Disruption of major neuronal networks, such as agenesis of the corpus callosum, may diminish the normal functional connectivity patterns. Therefore, functional connectivity in such patients cannot be fully demonstrated with fcMR imaging.

Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Publishing Authors By Initials

JA Maldjian,

For similar nervous system: neural pathways research abstracts see: nervous system: neural pathways research

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Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 22

Page Numbers: 294-300

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ISSN: 0195-6108

DAY: 14

MONTH: Feb

YEAR: 2001

Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Keywords Mesh Terms:

KEYWORDS: Neural Pathways

MESH TERMS: physiopathology

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Grant and Affiliation Information for Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging.

AFFILIATION: Department of Medical Physics, University of Wisconsin, Clinical Sciences Center, Madison 53792-3252, USA.

Country: United States

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MEDLINETA: AJNR Am J Neuroradiol

REFSOURCE: AJNR Am J Neuroradiol. 2001 Feb;22(2):23

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