[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide]

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Abstract Text:

Guanghua Zhu,Lihua Xia,Guanzhao Lai,Laiyu Li,Jianxun Huang,Xiaojiang Tang,

OBJECTIVE: To observe the effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide. METHODS: 4 groups of SD rats were treated with various dosages of fluoroacetamid(p.o.) and 2 groups of them were treated with acetamide(i.p.). The changes of cardiomyocytes and serum AST, LDH, CK, CK-MB and HBDH were measured at different intervals after poisoning. RESULTS: In the group treated with fluoroacetamid 8 mg/kg. bw, serum AST[(589.58 +/- 821.72) U/L], CK[(916.78 +/- 343.55) U/L], HBDH[(504.47 +/- 148.88) U/L] raised obviously compared with control[(187.70 +/- 46.87), (755.65 +/- 498.90), (347.25 +/- 228.40) U/L respectively] (P < 0.01), and the pathological findings such as degeneration, liquefactive necrosis and filtration of inflammatory cells in cardiac muscles were observed 24 hours later, while all the male dead within 3 days. In the group treated with fluoroacetamid 4 mg/kg. bw, serum LDH and HBDH rose significantly compared with control(P < 0.01) 5 day later. On the day of 10, myocardial enzymes restored in all experiment groups with some interstitial fibroblastic proliferation. The pathological changes were reduced in the group treated with acetamide synchronously (100 mg/kg. bw). CONCLUSION: Acute intoxication of fluoroacetamide could damage cardiomyocytes while acetamide could reduce the injury of them, but the injury was reversible. The levels of serum myocardial enzymes could be a usable index for early diagnosis.

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Publishing Authors By Initials

G Zhu,L Xia,G Lai,L Li,J Huang,X Tang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 300-3

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Aug

YEAR: 2002

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 8410840

[Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide]

AFFILIATION: Guangdong Provincial Center for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide Related Publications

• Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats.
• Levels of adrenomedullin and proadrenomedullin N-terminal 20 peptide in myocardium and aorta of spontaneously hypertensive rats and Wistar-Kyoto rats.
• Sidearm approach: a promising strategy for construction of bisoxazoline-based ligand library.
• Surface X-ray scattering system at the SRRC.
• [A discussion on Zhang Cigong's materia medica]
• [A pedigree with myotonic dystrophy: non-CTG, non-CCTG repeat expansion]
• [A rapid method for diagnosing alpha-thalassemia-1 of Southeast Asia type]
• [Achievements in the research on the prevention and treatment of malaria in China]
• [An experimental study on the effects of wild type p16 gene on the proliferation and metabolism of human keloid fibroblasts]
• [Axis registration and image interpolation of rotary scanning echocardiogram]
• [Changes in adrenomedullin and receptor activity-modifying protein 2 mRNA in myocardium and vessels during L-NNA-induced hypertension in rats]
• [Comparative study on three different methods in typing hepatitis C virus]
• [Effect of fluoroacetamide on cardiomyocytes of rat and the antidotal effect of acetamide]
• [Effect of urotensin II on the nitric oxide production in neonatal rat cardiomyocytes]
• [Effects of peptides originated from the proadrenomedullin on the production of nitric oxide in rat aorta]
• [Experiences of prevention and treatment of infectious diseases in Chinese Soviet Republic]
• [Expression of bone morphogenetic protein (BMP)-2, 4 in mouse embryonic tooth during the bud stage]
• [Histological and ultrastructural variations after radiofrequency for soft palate in porcines]
• [Penile reconstruction by using a scapular free flap]
• [Preliminary experimental study on treatment of portal hypertension with auxiliary partial orthotopic liver transplantation.]
• [Preventive effect of endothelin-1 pretreatment on hypoxia-induced injury in cultured neonatal rat cardiomyocytes]
• [Prospect of the foveola formation in the bovine trabecular bone under fatigue process]
• [Protective effect and mechanism of morphine on acute myocardial ischemia/reperfusion injury in rats]
• [Relationship between the genotype of Candida albicans and oral lichen planus]
• [Repair of eyelid defect with a prefabricated flap]
• [Role of neurokinin-1 receptor in lung injury in rats with acute necrotizing pancreatitis]
• [The effect of liposome-carried metallothionein on secondary venous ischemia-reperfusion injury in a rat flap]
• [The influence of the LPS from bacteroides fragilis on the secretion of IL-2 and IL-4 from the peripheral blood mononuclear cells of normal volunteers]
• [The initiation of G2/M checkpoint by diallyl disulfide requires the activation of p38 MAP kinase in HL-60 cells]
• [The regulatory effect of endogenous hydrogen sulfide on hypoxic pulmonary hypertension]