Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions.

Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Research Abstract Details 

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Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Abstract Text:

Hajime Yamazaki,Amy Litman,Henry C Margolis,Hajime Yamazaki,Amy Litman,Henry C Margolis,

OBJECTIVE: This study was carried out to determine in vitro the effect of fluoride on (1) the demineralization of sound human enamel and (2) the progression of artificial caries-like lesions, under relevant oral conditions. METHODS: Thin sections of sound human enamel were exposed to solutions undersaturated with respect to tooth enamel to a degree similar to that found in dental plaque fluid following sucrose exposure in vivo, containing fluoride concentrations (0-0.38ppm) found in plaque fluid. Mineral changes were monitored for 98 days, using quantitative microradiography. The effect of fluoride (1.0-25.0ppm) on the progression of artificial caries-like lesions was similarly studied. RESULTS: Fluoride concentrations of 0.19ppm and greater were found to prevent the demineralization of sound enamel in vitro. However, significantly higher concentrations of fluoride (25.0ppm) were required to prevent further demineralization of artificial caries-like lesions. Demineralizing solutions with intermediate fluoride concentrations (2.1-10.1ppm) induced simultaneously remineralization in the outer portion of the lesion and demineralization in the inner portion. Simultaneous remineralization and demineralization were also observed in hydroxyapatite pellets. CONCLUSIONS: Our results show that the observed effect of fluoride on enamel demineralization is not solely a function of bulk solution properties, but also depends on the caries-status of the enamel surface. A mechanistic model presented indicates that, in comparison to sound enamel surfaces, higher concentrations of fluoride are required to prevent the progression of artificial caries-like lesions under in vivo-like conditions since the diffusion of mineral ions that promote remineralization is rate-limiting.

Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Publishing Authors By Initials

H Yamazaki,A Litman,HC Margolis,H Yamazaki,A Litman,HC Margolis,

For similar dentistry: tooth remineralization research abstracts see: dentistry: tooth remineralization research

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Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of oral biology

VOLUME: 52

Page Numbers: 110-20

Journal Abbreviation: Arch. Oral Biol.

ISSN: 0003-9969

DAY: 16

MONTH: 10

YEAR: 2006

Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 116711

Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Keywords Mesh Terms:

KEYWORDS: Tooth Remineralization

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions. Information

Substance Name: Fluorides

Registry Number: 0

Grant and Affiliation Information for Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions.

AFFILIATION: Health Care Products Research Laboratories, Kao Corporation, 1-3, Bunka 2 chome, Sumidaku, Tokyo 131-8501, Japan. hyamazaki@forsyth.org

Country: England

AGENCY: United States NIDCR

GRANT: DE-15163

ACRONYM: DE

MEDLINETA: Arch Oral Biol

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