[Effect of early exposure to allergen on rat asthmatic model]

[Effect of early exposure to allergen on rat asthmatic model] Research Abstract Details 

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[Effect of early exposure to allergen on rat asthmatic model] Abstract Text:

Wen-ling Luo,Hai-chao Li,Hong-jun Hao,Li Su,

OBJECTIVE: To investigate the effect of early exposure to allergen (ovalbumin, OVA) on rat asthmatic models. METHODS: Neonate rats were randomly divided into negative control group, asthmatic model group, low dose group and high dose group, with 8 in each. The rats of low dose group and high dose group were injected subcutaneously with 2 g/L OVA 0.1 mL and 10 g/L OVA 0.1 mL separately on the 1st day. OVA was given in asthmatic model group, low dose group and high dose group for allerginizing 6 weeks later and then asthmatic models were made. The pathologic changes of lung tissue, cell count and differentiation of bronchoalveolar lavage fluid (BALF) and serum interleukin-4 (IL-4), interferon-gamma (IFN-gamma), OVA-specific IgE and OVA-specific IgG were observed. RESULTS: The airway inflammation in both low dose group and high dose group was less severe than that in asthmatic model group. Total cell count of BALF and the ratio of eosinophil and neutrophil of both groups were decreased significantly compared with asthmatic model group. IL-4 and OVA-specific IgE were markedly decreased, while IFN-gamma was significantly increased in both low dose group and high dose group compared with asthmatic model group respectively. There was no significant difference in IL-4, IFN-gamma and OVA-specific IgE between high dose group and control group. The serum OVA-specific IgG was elevated significantly in asthmatic model group, low dose group and high dose group compared with control group, and it was higher in high dose group than in asthmatic model group. CONCLUSION: Early exposure to OVA after birth could inhibit the airway inflammation and OVA-specific IgE increasing induced by OVA in grown-up rats, and the mechanisms might be related to formation of immunology tolerance.

[Effect of early exposure to allergen on rat asthmatic model] Publishing Authors By Initials

WL Luo,HC Li,HJ Hao,L Su,

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[Effect of early exposure to allergen on rat asthmatic model] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe

VOLUME: 38

Page Numbers: 159-63

Journal Abbreviation: Beijing Da Xue Xue Bao

ISSN: 1671-167X

DAY: 18

MONTH: Apr

YEAR: 2006

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LANGUAGE: chi

NlmUniqueID: 101125284

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Grant and Affiliation Information for [Effect of early exposure to allergen on rat asthmatic model]

AFFILIATION: Department of Respiratory Medicine, Peking University First Hospital, Beijing 100034, China.

Country: China

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MEDLINETA: Beijing Da Xue Xue Bao

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