Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats.

Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. Research Abstract Details 

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Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. Abstract Text:

Michael Schwarz,Bertram Poch,Rainer Isenmann,Dietrich Kriese,Eva Rozdzinski,Hans G Beger,Frank Gansauge,Michael Schwarz,Bertram Poch,Rainer Isenmann,Dietrich Kriese,Eva Rozdzinski,Hans G Beger,Frank Gansauge,

BACKGROUND: The clinical course in acute necrotizing pancreatitis is mainly determined by bacterial infection of pancreatic and peripancreatic necrosis. The effect of two antibiotic regimens for early and late treatment was investigated in the taurocholate model of necrotizing pancreatitis in the rat. MATERIALS AND METHODS: Seventy male Wistar rats were divided into five pancreatitis groups (12 animals each) and a sham-operated group (10 animals). Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals received two different antibiotic regimes (20 mg/kg imipenem or 20 mg/kg ciprofloxacin plus 20 mg/kg metronidazole) early at 2, 12, 20, and 28 h after induction of pancreatitis or late at 16 and 24 h after induction of pancreatitis or no antibiotics (control). Animals were examined after 30 h for pancreatic and extrapancreatic infection. RESULTS: Early and late antibiotic treatment with both regimes could significantly reduce pancreatic infection from 58 to 8-25%. However, extrapancreatic infection was only reduced by early antibiotic therapy. While quinolones also reduced bacterial counts in small and large bowel, imipenem did not. CONCLUSIONS: In our animal model of necrotizing pancreatitis, early and late treatment with ciprofloxacin/metronidazole and imipenem reduce bacterial infection of the pancreas. Extrapancreatic infection, however, is reduced significantly only by early antibiotic treatment. The effectivity of early antibiotic treatment in the clinical setting should be subject to further investigation with improved study design and sufficient patient numbers.

Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. Publishing Authors By Initials

M Schwarz,B Poch,R Isenmann,D Kriese,E Rozdzinski,HG Beger,F Gansauge,M Schwarz,B Poch,R Isenmann,D Kriese,E Rozdzinski,HG Beger,F Gansauge,

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Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Langenbeck's archives of surgery / Deutsche Gesell

VOLUME: 392

Page Numbers: 365-70

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ISSN: 1435-2443

DAY: 23

MONTH: 03

YEAR: 2007

Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. Information

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LANGUAGE: eng

NlmUniqueID: 9808285

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Grant and Affiliation Information for Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats.

AFFILIATION: Department of General Surgery, University of Ulm, Ulm, Germany. michael.schwarz@eurosurgery.de

Country: Germany

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MEDLINETA: Langenbecks Arch Surg

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