Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.

Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. Research Abstract Details 

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Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. Abstract Text:

Mijin Han,Yu-Lee Kim,Santosh J Sacket,Kyeok Kim,Hyo-Lim Kim,Ji-Yeong Jo,Nam-Chul Ha,Dong-Soon Im,Mijin Han,Yu-Lee Kim,Santosh J Sacket,Kyeok Kim,Hyo-Lim Kim,Ji-Yeong Jo,Nam-Chul Ha,Dong-Soon Im,Mijin Han,Yu-Lee Kim,Santosh J Sacket,Kyeok Kim,Hyo-Lim Kim,Ji-Yeong Jo,Nam-Chul Ha,Dong-Soon Im,

We investigated the effects of serum on lysophospholipid-induced cytotoxicity in Jurkat T cells. We found that sphingosylphosphorylcholine (SPC, also known as lysosphingomyelin) induced cytotoxicity and that albumin in serum could protect cells by binding directly to SPC. Furthermore, we also found that SPC induced ROS generation, increased [Ca(2+)](i), and decreased MMP. However, those effects were only observed at concentrations higher than 10muM and were only induced in albumin-free media. Therefore, SPC may be trapped by albumin in plasma and unable to exert its effects under normal conditions, although at high concentrations, SPC could induce several responses such as ROS generation, increased [Ca(2+)](i), and decreased MMP in Jurkat T cells.

Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. Publishing Authors By Initials

M Han,YL Kim,SJ Sacket,K Kim,HL Kim,JY Jo,NC Ha,DS Im,M Han,YL Kim,SJ Sacket,K Kim,HL Kim,JY Jo,NC Ha,DS Im,M Han,YL Kim,SJ Sacket,K Kim,HL Kim,JY Jo,NC Ha,DS Im,

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Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Prostaglandins & other lipid mediators

VOLUME: 84

Page Numbers: 174-83

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ISSN: 1098-8823

DAY: 4

MONTH: 09

YEAR: 2007

Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. Information

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LANGUAGE: eng

NlmUniqueID: 9808648

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AFFILIATION: Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

Country: United States

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MEDLINETA: Prostaglandins Other Lipid Med

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