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Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease.

Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Research Abstract Details 

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  • Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Abstract Text:

    t kobayashiT Kobayashi,k soneK Sone,

    Dipyridamole has been widely used in Japan to treat patients with a coronary aneurysm resulting from Kawasaki disease, but its effect in these patients has not been established. In the present study we assessed the effect of dipyridamole on the coronary arteries of patients with a history of Kawasaki disease by measuring the diameter of the coronary arteries and by quantifying the disappearance time of contrast medium (runoff time) on coronary angiography. Intravenous injection of dipyridamole increased the diameter of nondilated arteries by 7.9%. Its effect on the diameter of dilated coronary arteries (coronary aneurysm) was less than 3% (p < 0.01). Runoff time of dilated coronary arteries was significantly (p < 0.01) greater than that of nondilated coronary arteries. Dipyridamole accelerated runoff time not only in nondilated coronary arteries (p < 0.01) but also in coronary arteries with various degrees of dilatation (p < 0.01). We conclude that dipyridamole increases blood flow in coronary arteries without dilating the proximal aneurysm in children with a history of Kawasaki disease.

    Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Publishing Authors By Initials

    t kobayashiT Kobayashi,k soneK Sone,

    For similar cardiovascular diseases: vascular diseases: vasculitis: mucocutaneous lymph node syndrome research abstracts see: cardiovascular diseases: vascular diseases: vasculitis: mucocutaneous lymph node syndrome research

    PUBMED ID PMID:

    MEDLINE DATE: 1994 Nov-Dec

    Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Pediatric cardiology

    VOLUME: 15

    Page Numbers: 263-7

    Journal Abbreviation: Pediatr Cardiol

    ISSN: 0172-0643

    DAY: 20

    MONTH: 02

    YEAR: 2008

    Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8003849

    Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Keywords Mesh Terms:

    KEYWORDS: Mucocutaneous Lymph Node Syndrome

    MESH TERMS: physiopathology

    Chemical & Substance for Abstract: Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Information

    Substance Name: Dipyridamole

    Registry Number: 58-32-2

    Grant and Affiliation Information for Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease.

    AFFILIATION: Department of Pediatrics, Gunma University School of Medicine, Japan.

    Country: UNITED STATES

    UNITED STATES Research PublicationUNITED STATES Research Publication

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    ACRONYM:

    MEDLINETA: Pediatr Cardiol

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