[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro]

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Abstract Text:

Junxia Min,Junsheng Guo,Faji Zhao,Donglian Cai,

To examine the effect of alpha-tocopherol(alpha-T), gamma-tocopherol(gamma-T), delta-tocopherol(delta-T), and vitamin E succinate (VES) on the proliferation of human hepatoma cell (HepG2), cell proliferation was detected by hemocytometer count, MTT assay and flow cytometry (FCM) with different VE homologues analogues (alpha-T, gamma-T, delta-T and VES) and different concentrations (12.5 mg/L, 25 mg/L, 50 mg/L, 100 mg/L and 200 mg/L). The results showed that The growth of HepG2 cells was inhibited by delta-T and VES at the dosages of 12.5-200 mg/L in comparison with the negative control group, while gamma-T showed weak effect of inhibition and alpha-T did not show any inhibition effect. The dose range to produce inhibition effects varied with different analogues. A dose-dependent inhibition of cell growth was found in HepG2 cell lines treated with different vitamin E homologues analogues. An accumulation of cells in G0/G1-phase and a significant decreasing of cells in S-phase were found as evaluated by flow cytometric analysis employing a PI-staining method. It is suggested that delta-tocopherol and VES decreased HepG2 cells growth and viability. A dose-dependent of anti-proliferation was found in HepG2 cells line. the order of efficiency of four vitamin E analogues was delta-tocopherol > VES > gamma-tocopherol > alpha-tocopherol. The proliferation was blocked in S-phase. The difference in nature and magnitude of the anticancer effects does not correlate with their reported relative antioxidant activity and might be due to minor differences in their structure important to their biological activities. These results suggest that delta-tocopherol and VES could be promising anti-hepatoma agents.

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Publishing Authors By Initials

J Min,J Guo,F Zhao,D Cai,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research

PUBMED ID PMID:

MEDLINE DATE:

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wei sheng yan jiu = Journal of hygiene research

VOLUME: 32

Page Numbers: 40-3

Journal Abbreviation:

ISSN: 1000-8020

DAY: 19

MONTH: Jan

YEAR: 2003

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9426367

[Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Keywords Mesh Terms:

KEYWORDS: gamma-Tocopherol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: [Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro] Information

Substance Name: alpha-Tocopherol

Registry Number: 59-02-9

Grant and Affiliation Information for [Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro]

AFFILIATION: Second Military Medical University, Shanghai 200433, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Wei Sheng Yan Jiu

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro Related Publications

• Expression of vascular endothelial growth factor and E26 transformation-specific-1 in breast carcinoma.
• [A related analysis for alpha, beta fibrinogen gene haplotypes and nucleotide polymorphisms associated with the ischemic stroke in Hainan Han population]
• [Advances in researches on genes and their pathophysiological implications of schizophrenia]
• [Application of atomic force microscopy in cell biology]
• [Cytomegalovirus infection of myeloma cell line KM3 and its effect on IL-6 mRNA expression in the cells]
• [Detection of 8-hydroxyguanine in the DNA of the H2O2-treated HL-60 cells by GC/FID]
• [Determination of deoxyribonucleic acid with nitro-tetrazolium chloride blue by resonance light-scattering technique]
• [Determination of dimethyl ether correction factors in gas chromatography with TCD and FID]
• [Determination of liensinine in plasma by high performance liquid chromatography]
• [Determination of prostaglandinum E1 by fluorescence extinction method]
• [Determination of soluble heavy metal Pb, Cd and Cr in water based architectural coatings for indoor decorating and refurbishing materials by ICP-AES]
• [Distribution and germination of Alexandrium sp. cysts in coastal areas of Southeast China Sea]
• [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells (HepG2)]
• [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)]
• [Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro]
• [Establishment of animal model for in vitro spermatogenesis by heterotopic grafting of neonatal mouse testis.]
• [Experimental study on repair of goat tibia defect with marrow stromal cell and bio-derived bone]
• [Gamma knife radiosurgery for hemangioblastomas: clinical results and pathological findings]
• [Generation of CD14+ dendritic cells in vitro with GM-CSF and IL-4]
• [Nitrogen and phosphorus absorption and growth characteristics of Alexandrium tamarense]
• [Perivascular epithelioid cell tumor (PEComa) of the uterine]
• [Progress in treatment of infantile spasms]
• [Relationship between the IFN-gamma producing cells specific for recipient and acute graft versus host disease]
• [Spectrophotometric studies on and applications of the reaction of copper with 2-hydroxy-3-carboxy-5-sulfobenzenediazoaminoazobenzene]
• [Study on the expressions of basic fibroblast growth factor and nervous growth factor genes in rat cerebral concussion]
• [Study on the level of environmental endocrine disruptors in serum of precocious puberty patients]
• [Surgical treatment of congenital anophthalmia]
• [The comparison between regenerated cortex and primary cortex of Cortex Cinnamomi on description and microscopic characters]
• [The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats]
• [Value of lymph node micrometastasis detected by RT-PCR assay in determining the stage of gastric carcinoma]