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[Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock]

[Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock] Research Abstract Details 

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  • [Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock] Abstract Text:

    xiaoqing liXiaoqing Li,lei dongLei Dong,jinyan luoJinyan Luo,

    OBJECTIVE: To examine the effect of different infusion volume on hemodynamics of portal hypertension (PHT) canines after hemorrhagic shock (HS). METHODS: PHT canine models were made by coarctating a half main portal vein with silk line chronic embolization. Two weeks later, the canine models were assigned to hemorrhagic shock by femoral artery venesection quickly. They were divided into two groups: large volume infusion group (n=6) and small volume infusion group (n=6). Hemodynamics indexes of PHT canines after HS were monitored continuously. We also examined the effect of different infusion volume on hemodynamics. RESULTS: PHT canines showed a series of hemodynamics changes in hemorrhagic shock stage, which aggravated hemodynamics disorder in PHT. After quick infusion, MAP, IVCP, PVP, PVPG, PVBF, HABF, and HBF increased significantly. These indexes in large volume infusion group were higher than those in small volume infusion group. PVR, SVR, HAR decreased significantly. PVP, PVPG, PVBF, HABF, and HBF showed a rebound increase above baseline values in large volume infusion group. The changes of PVP, PVPG, PVBF, HABF, and HBF were parallel with MAP and IVCP and without rebound increase in small volume infusion group. In large volume infusion group PVPG increased earlier and more significant than PVP and exceeded baseline by 13% (2.58 0.37) kPa, so the danger of rebleeding rose greatly. In small volume infusion group PVPG was over 22% (1.67 0.27) kPa lower than baseline, which infers that the danger of rebleeding reduced greatly. SVR and HAR were lower in large volume infusion group. PVP, PVPG, PVBF, HABF, and HBF showed a positive correlation with accumulated vein infusion volume. PVR showed a positive correlation with accumulated vein infusion volume in small volume infusion group. HAR showed a negative correlation with accumulated vein infusion volume in large volume infusion group. CONCLUSIONS: PHT canines after HS show a rebound increase of PVP, PVPG, PVBF, HABF, and HBF above baseline values in large volume infusion group. In small volume infusion group, however, no rebound increase is noticed. Large volume infusion may cause PVP, PVPG, PVBF, HABF, and HBF increase higher than small volume infusion.

    [Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock] Publishing Authors By Initials

    x liX Li,l dongL Dong,j luoJ Luo,

    For similar abstracts research abstracts see: abstracts research

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    [Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock] Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbi

    VOLUME: 10

    Page Numbers: 374-7

    Journal Abbreviation: Zhonghua Gan Zang Bing Za Zhi

    ISSN: 1007-3418

    DAY: 23

    MONTH: Oct

    YEAR: 2002

    [Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock] Information

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    LANGUAGE: chi

    NlmUniqueID: 9710009

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    Grant and Affiliation Information for [Effect of different infusion volume on hemodynamics of portal hypertension canines after hemorrhagic shock]

    AFFILIATION: Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

    Country: China

    China Research PublicationChina Research Publication

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    MEDLINETA: Zhonghua Gan Zang Bing Za Zhi

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