Effect of dibutyltin on ATP levels in human natural killer cells.

Effect of dibutyltin on ATP levels in human natural killer cells. Research Abstract Details 

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Effect of dibutyltin on ATP levels in human natural killer cells. Abstract Text:

Fred D Dudimah,Constance Gibson,Margaret M Whalen,

This study investigates the role that decreased ATP levels may play in dibutyltin (DBT)-induced decreases in the tumor-cell-lysing (lytic) function of natural killer (NK) cells. NK cells are a subset of lymphocytes capable of killing tumor cells, virally infected cells, and antibody coated cells. DBT is used as stabilizer in PVC plastics and has also been used as a deworming product in poultry. NK cells were exposed to various concentrations of DBT for 1 h, 24 h, 48 h, and 6 days before determining ATP levels and lytic function. ATP levels and lytic function were also determined in NK cells that were exposed to DBT for 1 h followed by 24 h, 48 h, and 6 days in DBT-free media. The results indicated that exposure of NK cells to 10 muM DBT for 1 h did not cause any significant decrease in NK cell ATP levels but did cause a very significant loss in lytic function. NK cells exposed to 500 nM DBT for 24 h showed significant loss of lytic function but showed no decrease in ATP levels. However, 48 h and 6 days exposures to those concentrations of DBT that caused decreases in tumor lysing function also caused significant decreases in ATP levels. Exposures of NK cells to varying DBT concentrations for 1 h followed by 24 h, 48 h, and 6 days in DBT free media produced effects on lytic function and ATP levels that were similar to those seen with continuous DBT exposures. The results indicate that DBT exposures decrease ATP levels in NK cells but that tumor lysing function can be reduced independent of any decreases in ATP levels. Additionally the results show that the effects of a range of DBT concentrations on ATP levels and tumor lysing function are irreversible.

Effect of dibutyltin on ATP levels in human natural killer cells. Publishing Authors By Initials

FD Dudimah,C Gibson,MM Whalen,

For similar organic chemicals: organometallic compounds: organotin compounds research abstracts see: organic chemicals: organometallic compounds: organotin compounds research

PUBMED ID PMID:

MEDLINE DATE:

Effect of dibutyltin on ATP levels in human natural killer cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Environmental toxicology

VOLUME: 22

Page Numbers: 117-23

Journal Abbreviation: Environ. Toxicol.

ISSN: 1520-4081

DAY: 3

MONTH: Apr

YEAR: 2007

Effect of dibutyltin on ATP levels in human natural killer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100885357

Effect of dibutyltin on ATP levels in human natural killer cells. Keywords Mesh Terms:

KEYWORDS: Organotin Compounds

MESH TERMS: toxicity

Chemical & Substance for Abstract: Effect of dibutyltin on ATP levels in human natural killer cells. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for Effect of dibutyltin on ATP levels in human natural killer cells.

AFFILIATION: Department of Biological Sciences, Tennessee State University, Nashville, Tennessee 37209, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 2S06GM-08092-28

ACRONYM: GM

MEDLINETA: Environ Toxicol

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