[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells]

[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells] Research Abstract Details 

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[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells] Abstract Text:

H Meng,X Lin,M Lin,

OBJECTIVE: To explore measures to overcome multidrug resistance of tumor cells. METHODS: The effects of cyclosporin A (CsA) on drug sensitivity, intracellular drug accumulation and drug efflux in multidrug-resistant human leukemic cell line K562/DOX were studied by MTT colorimetric assay and spectrofluorimetry. RESULTS: CsA enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX, and when CsA > or = 2microg/ml the sensitivity of K562/DOX to DOX increased significantly. The efflux of DOX markedly decreased when K562/DOX cells were incubated with 2microg/ml CsA, while CsA had no effect on efflux of DOX in K562 cells. CONCLUSION: CsA could markedly decrease the efflux and enhance the intracellular accumulation of DOX in K562/DOX cells.

[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells] Publishing Authors By Initials

H Meng,X Lin,M Lin,

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[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 254-6

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: May

YEAR: 1997

[Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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Grant and Affiliation Information for [Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells]

AFFILIATION: First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310003.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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