[Effect of curcumin on STAT5 signaling molecule in K562 cells]

[Effect of curcumin on STAT5 signaling molecule in K562 cells] Research Abstract Details 

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[Effect of curcumin on STAT5 signaling molecule in K562 cells] Abstract Text:

Wei-Hong Chen,Yan Chen,Jun-Xia Gu,Jing He,

OBJECTIVE: To investigate the effect of curcumin on STAT 5 signaling molecule in K562 cells and its molecular mechanism of antileukemia. METHODS: Cell proliferation was studied by tetrazolium dye assay. The expressions of STAT5 mRNA and protein were assayed by in situ hybridization, and Western blotting respectively. RESULTS: Curcumin could inhibit K562 cell proliferation in a time- and dose-dependent manner. The percentage of STAT5-positive cells was 19% in curcunin group, significantly less than 31% of that in K562 cell group (P < 0.01). The A value of the expression level of STAT5 protein in curcumin group was 15 266 +/- 769, significantly less than 25 781 +/- 1240 of that in K562 cell group (P < 0.01). CONCLUSION: The expressions of STAT5 mRNA and protein in K562 cells were inhibited by curcumin and curcumin could inhibit K562 cell proliferation.

[Effect of curcumin on STAT5 signaling molecule in K562 cells] Publishing Authors By Initials

WH Chen,Y Chen,JX Gu,J He,

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[Effect of curcumin on STAT5 signaling molecule in K562 cells] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 151-3

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 8

MONTH: Mar

YEAR: 2004

[Effect of curcumin on STAT5 signaling molecule in K562 cells] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Department of Hematology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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