Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Abstract Text:

Anil Kumar,P S Naidu,N Seghal,S S V Padi,Anil Kumar,P S Naidu,N Seghal,S S V Padi,

This study was designed to investigate the protective effects of curcumin against colchicine-induced cognitive impairment and oxidative stress in rats. Male Wistar rats (weighing 150-200 g) received colchicine intracerebroventricularly (15 microg per rat), and cognitive dysfunctions were evaluated by the Morris water maze and the plus maze performance task and supported by biochemical tests. Central administration of colchicine caused memory deficit in both the Morris water maze and the elevated plus maze task paradigm tasks. Chronic treatment with curcumin (5-50 mg/kg, p.o.) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment. Biochemically, chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the decreased reduced glutathione level and acetylcholinesterase activity, and attenuated the raised colchicine-induced elevated nitrite levels. The results of the present study indicate that curcumin has a protective role against colchicine-induced cognitive impairment and associated oxidative stress.

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Publishing Authors By Initials

A Kumar,PS Naidu,N Seghal,SS Padi,A Kumar,PS Naidu,N Seghal,SS Padi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medicinal food

VOLUME: 10

Page Numbers: 486-94

Journal Abbreviation:

ISSN: 1096-620X

DAY: 24

MONTH: Sep

YEAR: 2007

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9812512

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.

AFFILIATION: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. kumaruips@yahoo.com

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Med Food

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats Related Publications

• Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.
• Neuroendocrine dysfunction in schizophrenia: a familial perspective.