Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.

Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Research Abstract Details 

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Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Abstract Text:

Edward P Acosta,Michelle A Kendall,John G Gerber,Beverly Alston-Smith,Susan L Koletar,Andrew R Zolopa,Sangeeta Agarwala,Michael Child,Richard Bertz,Lara Hosey,David W Haas,Edward P Acosta,Michelle A Kendall,John G Gerber,Beverly Alston-Smith,Susan L Koletar,Andrew R Zolopa,Sangeeta Agarwala,Michael Child,Richard Bertz,Lara Hosey,David W Haas,

The potent induction of hepatic cytochrome P450 3A isoforms by rifampin complicates therapy for coinfection with human immunodeficiency virus (HIV) and Mycobacterium tuberculosis. We performed an open-label, single-arm study to assess the safety and pharmacokinetic interactions of the HIV protease inhibitor atazanavir coadministered with rifampin. Ten healthy HIV-negative subjects completed pharmacokinetic sampling at steady state while receiving 300 mg atazanavir every 12 h without rifampin (period 1), 300 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 2), and 400 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 3). During period 1, the mean concentration of drug in serum at 12 h (C(12 h)) was 811 ng/ml (range, 363 to 2,484 ng/ml) for atazanavir, similar to historic seronegative data for once-daily treatment with 300 mg atazanavir boosted with 100 mg ritonavir. During periods 2 and 3, the mean C(12 h) values for atazanavir were 44 ng/ml (range, <25 to 187 ng/ml) and 113 ng/ml (range, 39 to 260 ng/ml), respectively, well below historic seronegative data for once-daily treatment with 400 mg atazanavir without ritonavir. Although safe and generally well tolerated, 300 mg or 400 mg atazanavir administered every 12 h did not maintain adequate plasma exposure when coadministered with rifampin.

Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Publishing Authors By Initials

EP Acosta,MA Kendall,JG Gerber,B Alston-Smith,SL Koletar,AR Zolopa,S Agarwala,M Child,R Bertz,L Hosey,DW Haas,EP Acosta,MA Kendall,JG Gerber,B Alston-Smith,SL Koletar,AR Zolopa,S Agarwala,M Child,R Bertz,L Hosey,DW Haas,

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Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 3104-10

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 18

MONTH: 06

YEAR: 2007

Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Information

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LANGUAGE: eng

NlmUniqueID: 315061

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Grant and Affiliation Information for Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.

AFFILIATION: University of Alabama at Birmingham, Birmingham, Alabama, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00095

ACRONYM: RR

MEDLINETA: Antimicrob Agents Chemother

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