Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study.

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Abstract Text:

Carmen Andreescu,Eric J Lenze,Mary Amanda Dew,Amy E Begley,Benoit H Mulsant,Alexandre Y Dombrovski,Bruce G Pollock,Jacqueline Stack,Mark D Miller,Charles F Reynolds,

BACKGROUND: Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment. AIMS: To examine whether anxiety symptoms predict acute and maintenance (2 years) treatment response in late-life depression. METHOD: Data were drawn from a randomised double-blind study of pharmacotherapy and interpersonal psychotherapy for patients age 70 years and over with major depression. Anxiety symptoms were measured using the Brief Symptom Inventory. Survival analysis tested the effect of pre-treatment anxiety on response and recurrence. RESULTS: Patients with greater pretreatment anxiety took longer to respond to treatment and had higher rates of recurrence. Actuarial recurrence rates were 29% (pharmacotherapy, lower anxiety), 58% (pharmacotherapy, higher anxiety), 54% (placebo, lower anxiety) and 81% (placebo, higher anxiety). CONCLUSIONS: Improved identification and management of anxiety in late-life depression are needed to achieve response and stabilise recovery.

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Publishing Authors By Initials

C Andreescu,EJ Lenze,MA Dew,AE Begley,BH Mulsant,AY Dombrovski,BG Pollock,J Stack,MD Miller,CF Reynolds,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

PUBMED ID PMID:

MEDLINE DATE:

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of psychiatry : the journal of

VOLUME: 190

Page Numbers: 344-9

Journal Abbreviation:

ISSN: 0007-1250

DAY: 3

MONTH: Apr

YEAR: 2007

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 342367

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Information

Substance Name: Serotonin Uptake Inhibitors

Registry Number: 0

Grant and Affiliation Information for Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study.

AFFILIATION: Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Room E 823, Pittsburgh, PA15213, USA. Lenzee@upmc.edu.

Country: England

AGENCY: United States NIMH

GRANT: R37 MH43832

ACRONYM: MH

MEDLINETA: Br J Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study Related Publications

• A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia.
• A review of delay-discounting research with humans: relations to drug use and gambling.
• Accelerating lumbar fusions by combining rhBMP-2 with allograft bone: a prospective analysis of interbody fusion rates and clinical outcomes.
• Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old age.
• An Intent-to-Treat Method for Enhancing Analysis of Clinical Trials with Rescue Medication: A Mixed-Model Approach.
• Anne L. Davis, m.d.: 1925-2003.
• Barbaloin in aloe species.
• Birth characteristics and risk of neuroblastoma in young children.
• Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension.
• Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study.
• Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age.
• Ethical considerations in the conduct of electronic surveillance research.
• Event perception: a mind-brain perspective.
• Expanding the usefulness of Interpersonal Psychotherapy (IPT) for depressed elders with co-morbid cognitive impairment.
• Feeding rumen-inert fats differing in their degree of saturation decreases intake and increases plasma concentrations of gut peptides in lactating dairy cows.
• Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells.
• Hemlock Alkaloids in Aloes. Occurrence and Distribution of gamma-Coniceine.
• Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-X-SORB organized lipid complex.
• Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model.
• Mitochondrial trafficking and morphology in healthy and injured neurons.
• Placental growth throughout the last two thirds of pregnancy in sheep: vascular development and angiogenic factor expression.
• Plasma concentrations of gut peptides in dairy cattle increase after calving.
• Sleep in healthy seniors: a diary study of the relation between bedtime and the amount of sleep obtained.
• Stimulus-specific competitive selection in macaque extrastriate visual area V4.
• Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).
• Temporal resolution for the perception of features and conjunctions.
• The Opi1p transcription factor affects expression of FLO11, mat formation, and invasive growth in Saccharomyces cerevisiae.
• Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection.
• p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
• p120-catenin: Past and present.