Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers.

Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers. Research Abstract Details 

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Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers. Abstract Text:

P M Zavos,M G Burchett,L A Edgerton,

The objective of this study was to determine the effect of clomiphene citrate (clomid) on pituitary responsiveness to gonadotropin releasing hormone (GnRH) in rams and wethers. Doses of 200 mg clomid per ram and 1 mug GnRH per 50 kg body weight were used in studies on 12 rams and 4 wethers. The experimental design involved bleeding each animal at 15-minute intervals for 6.5 hours. At the end of the first hour, GnRH was injected IV. The second GnRH challenge was administered 0.5 hours after an injection of clomid or vehicle (4.5% sorbitol solution) which was given on the third hour. The relative response to clomid or vehicle was calculated as the mean increase in concentration of LH during the two-hour period after the second GnRH injection. Each treatment (clomid and vehicle) was given to all animals with a 14-day recovery period between treatment days. The relative response for the rams receiving vehicle (1.80 +/- 0.65) was greater (P < 0.05) than the response during clomid treatment (0.34 +/- 0.22). This suppression of LH response by clomid was observed in 10 of the 12 rams. In contrast to the rams, the concentrations of LH in wethers after the second GnRH injection were lower than those observed after the first GnRH injection. Similar to the rams, the relative response following clomid treatment of wethers (0.04 +/- 0.04) was less than the relative response (P > 0.05) following vehicle (0.40 +/- 0.16). The results suggest that clomid at this dosage inhibits GnRH-induced release of LH from the pituitary of rams but not of wethers.

Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers. Publishing Authors By Initials

PM Zavos,MG Burchett,LA Edgerton,

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Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Theriogenology

VOLUME: 22

Page Numbers: 75-82

Journal Abbreviation: Theriogenology

ISSN: 0093-691X

DAY: 26

MONTH: Jul

YEAR: 1984

Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of clomiphene citrate on pituitary responsiveness to gonadotropin releasing hormone in rams and wethers.

AFFILIATION: Department of Animal Sciences, University of Kentucky Lexington, KY 40546-0215 USA.

Country: United States

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MEDLINETA: Theriogenology

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