Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects.

Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Research Abstract Details 

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Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Abstract Text:

James M Roza,Zheng Xian-Liu,Najla Guthrie,James M Roza,Zheng Xian-Liu,Najla Guthrie,

CONTEXT: Preliminary studies have suggested that both citrus flavonoids and palm tocotrienols reduce cholesterol levels in laboratory animals. OBJECTIVE: To examine the effect of these nutrients in combination on blood levels of cholesterol and related cardiovascular disease risk factors. DESIGN: Two open-label studies and 1 double-blind study are reported. SETTING: Outpatient clinical research setting. PATIENTS: Three groups (n=10, n=10, n=120) of hypercholesterolemic men and women (cholesterol levels >230 mg/dL) between the ages of 19 and 65 years were recruited. INTERVENTION: Subjects were randomized to consume either 270 mg citrus flavonoids plus 30 mg tocotrienols (S) or placebo (P) daily for a period of 4 weeks (group 1 [G1] and group 2 [G2]) or 12 weeks (group 3 [G3]). MAIN OUTCOME MEASURES: Measurements of fasting levels of blood cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were made at baseline and 4 weeks (all groups) and at 8 weeks and 12 weeks (G3). RESULTS: Daily treatment with S significantly improved cardiovascular parameters compared to P in all groups. Significant reductions were shown in total cholesterol (20%-30%), LDL (19%-27%), apolipoprotein B (21%), and triglycerides (24%-34%). HDL levels remained unchanged in G1 and G2 but increased 4% (nonsignificant) in G3 and was accompanied by a significant increase in apolipoprotein A1 (5%).

Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Publishing Authors By Initials

JM Roza,Z Xian-Liu,N Guthrie,JM Roza,Z Xian-Liu,N Guthrie,

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Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alternative therapies in health and medicine

VOLUME: 13

Page Numbers: 44-8

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ISSN: 1078-6791

DAY: 7

MONTH: 11

YEAR: 2007

Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Information

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LANGUAGE: eng

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AFFILIATION: SourceOne Global Partners, Chicago, Illinois, USA.

Country: United States

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MEDLINETA: Altern Ther Health Med

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