Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication.

Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication. Research Abstract Details 

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Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication. Abstract Text:

Hon-Yan Han,Jae-Rin Lee,Wei-An Xu,Myong-Joon Hahn,Jun-Mo Yang,Yong-Doo Park,Hon-Yan Han,Jae-Rin Lee,Wei-An Xu,Myong-Joon Hahn,Jun-Mo Yang,Yong-Doo Park,

Tyrosinase plays a core role in melanogenesis of the various organisms. Therefore, the regulation of the tyrosinase activity is directly related with melanin synthesis. In this study, we investigated the Cl(-)-induced inhibition of human tyrosinase and the potent role of Cl(-) as a negative regulator in melanogenesis. For the inhibition kinetic studies, human tyrosinase was differently prepared from the TXM13 melanotic cells as well as from cells that had undergone gene transfection. We found that Cl(-) inhibited tyrosinase in a slope-parabolic competitive manner and tyrosinase gene transfection into HEK293 cell significantly down-regulated the expression levels of solute carrier family 12, member 4 (potassium/chloride transporters, SLC12A7) and solute carrier family 12, member 7 (potassium/chloride transporters, SLC12A7), which are known to be Cl(-) transporters. From the results of the inhibition kinetic studies and the Cl(-) transporter expression level, we suggested that Cl(-) might act as a potent regulatory factor in melanogenesis. It is worth notice that a high content of Cl(-) exists physiologically and tyrosinase reacts sensitively to Cl- in a complex interaction manner.

Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication. Publishing Authors By Initials

HY Han,JR Lee,WA Xu,MJ Hahn,JM Yang,YD Park,HY Han,JR Lee,WA Xu,MJ Hahn,JM Yang,YD Park,

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Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomolecular structure & dynamics

VOLUME: 25

Page Numbers: 165-71

Journal Abbreviation: J. Biomol. Struct. Dyn.

ISSN: 0739-1102

DAY: 27

MONTH: Oct

YEAR: 2007

Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication. Information

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LANGUAGE: eng

NlmUniqueID: 8404176

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Grant and Affiliation Information for Effect of CI- on tyrosinase: complex inhibition kinetics and biochemical implication.

AFFILIATION: Department of Biology, College of Life Sciences, Soochow University, Suzhou 215123, PR China.

Country: United States

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MEDLINETA: J Biomol Struct Dyn

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