Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys.

Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Research Abstract Details 

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Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Abstract Text:

Glenn T Konopaske,Karl-Anton Dorph-Petersen,Robert A Sweet,Joseph N Pierri,Wei Zhang,Allan R Sampson,David A Lewis,

BACKGROUND: Both in vivo and postmortem studies suggest that oligodendrocyte and myelination alterations are present in individuals with schizophrenia. However, it is unclear whether prolonged treatment with antipsychotic medications contributes to these disturbances. We recently reported that chronic exposure of macaque monkeys to haloperidol or olanzapine was associated with a 10%-18% lower glial cell number in the parietal grey matter. Consequently, in this study we sought to determine whether the lower glial cell number was due to fewer oligodendrocytes as opposed to lower numbers of astrocytes. METHODS: With fluorescent immunocytochemical techniques, we optimized the visualization of each cell type throughout the entire thickness of tissue sections, while minimizing final tissue shrinkage. As a result, we were able to obtain robust stereological estimates of total oligodendrocyte and astrocyte numbers in the parietal grey matter with the optical fractionator method. RESULTS: We found a significant 20.5% lower astrocyte number with a non-significant 12.9% lower oligodendrocyte number in the antipsychotic-exposed monkeys. Similar effects were seen in both the haloperidol and olanzapine groups. CONCLUSIONS: These findings suggest that studies investigating glial cell alterations in schizophrenia must take into account the effect of antipsychotic treatment.

Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Publishing Authors By Initials

GT Konopaske,KA Dorph-Petersen,RA Sweet,JN Pierri,W Zhang,AR Sampson,DA Lewis,

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Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 63

Page Numbers: 759-65

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 22

MONTH: 10

YEAR: 2007

Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys.

AFFILIATION: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH71533

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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