Effect of carbon dioxide on neonatal mouse lung: a genomic approach.

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Abstract Text:

Guangyu Li,Dan Zhou,Alfin G Vicencio,Julie Ryu,Jin Xue,Amjad Kanaan,Orit Gavrialov,Gabriel G Haddad,

Despite the deleterious effects associated with elevated carbon dioxide (CO(2)) or hypercapnia, it has been hypothesized that CO(2) can protect the lung from injury. However, the effects of chronic hypercapnia on the neonatal lung are unknown. Hence, we investigated the effect of chronic hypercapnia on neonatal mouse lung to identify genes that could potentially contribute to hypercapnia-mediated lung protection. Newborn mouse litters were exposed to 8% CO(2), 12% CO(2), or room air for 2 wk. Lungs were excised and analyzed for morphometric alterations. The alveolar walls of CO(2)-exposed mice appeared thinner than those of controls. Analyses of gene expression differences by microarrays revealed that genes from a variety of functional categories were differentially expressed following hypercapnia treatment, including those encoding growth factors, chemokines, cytokines, and endopeptidases. In particular and of major interest, the expression level of genes encoding surfactant proteins A and D, as well as chloride channel calcium-activated 3, were significantly increased, but the expression of WNT1-inducible signaling pathway protein 2 was significantly decreased. The significant changes in gene expression occurred mostly at 8% CO(2), but only a few at 12% CO(2). Our results lead us to conclude that 1) there are a number of gene families that may contribute to hypercapnia-mediated lung protection; 2) the upregulation of surfactant proteins A and D may play a role as anti-inflammatory or antioxidant agents; and 3) the effects of CO(2) seem to depend on the level to which the lung is exposed.

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Publishing Authors By Initials

G Li,D Zhou,AG Vicencio,J Ryu,J Xue,A Kanaan,O Gavrialov,GG Haddad,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: respiratory system agents: pulmonary surfactants research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: respiratory system agents: pulmonary surfactants research

PUBMED ID PMID:

MEDLINE DATE:

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 101

Page Numbers: 1556-64

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 3

MONTH: 08

YEAR: 2006

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8502536

Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Keywords Mesh Terms:

KEYWORDS: Pulmonary Surfactants

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Information

Substance Name: Carbon Dioxide

Registry Number: 124-38-9

Grant and Affiliation Information for Effect of carbon dioxide on neonatal mouse lung: a genomic approach.

AFFILIATION: Department of Pediatrics, University of California San Diego, San Diego, California 92093-0735, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL-66327

ACRONYM: HL

MEDLINETA: J Appl Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of carbon dioxide on neonatal mouse lung: a genomic approach Related Publications

• 2006 Lebanese radiology workforce report.
• A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.
• Activity of the beta-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism.
• Adverse effects of antipsychotics as outcome measures.
• Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.
• CT scan findings of occult sinus pathology in asymptomatic individuals.
• Cell death in an ischemic infarct rim model.
• Chronic high-inspired CO2 decreases excitability of mouse hippocampal neurons.
• Delayed traumatic intracerebral hematoma: Case report and review of literature.
• Development of discriminatory multiple-locus variable number tandem repeat analysis for Bartonella henselae.
• Discordant tissue-specific expression of SAPK/MAPK(JNK)-related cofactors in hypoxia and hypoxia/reoxygenation in a model of anoxia-tolerance.
• Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia.
• Effect of carbon dioxide on neonatal mouse lung: a genomic approach.
• Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
• Factors influencing cell fate in the infarct rim.
• Fluorinated ethylenepropylene copolymer as a potential capillary material in CE.
• Hypoxia increases BK channel activity in the inner mitochondrial membrane.
• Identification of inorganic improvised explosive devices by analysis of postblast residues using portable capillary electrophoresis instrumentation and indirect photometric detection with a light-emitting diode.
• Insulin-sensitizing and Anti-proliferative Effects of Argania spinosa Seed Extracts.
• Male infertility.
• Prevalence and characteristics of metabolic syndrome in 111 Royal Jordanian Air Force pilots.
• Prostaglandin transporter expression in mouse brain during development and in response to hypoxia.
• Regulation of the Antisense Beta Myosin Heavy Chain Promoter: 939: June 2 9:45 AM - 10:00 AM.
• Reliable electrophoretic mobilities free from Joule heating effects using CE.
• Synthesis and secretion of transferrin by a bovine trabecular meshwork cell line.
• The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK(ERK): discordant proteomic effect of MAPK(p38).
• The time of perception and the other way around.
• [Description of an outbreak of lepidopterism (dermatitis associated with contact with moths) among sailors in Salvador, State of Bahia]
• [Illusions: a window into perception]
• [The "de Sèze" magnetic imaging]