Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction.

Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. Research Abstract Details 

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Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. Abstract Text:

Mingmin Zhang,Yuqin Huang,Guijin Zhu,Guangying Huang,Liping Dong,Jinjin Zhang,

In order to observe the effect of Bushenantai recipe on the expression of endometrial leukemia-inhibitory factor (LIF) in mice with embryonic implantation dysfunction (EID), 120 Kunming mice post coition were randomized into three groups: normal control group, model group and traditional Chinese medicine group (TCM group) (n=40 in each group). Uterus was collected on the pregnancy day (Pd) 4, 5, 6 after an intravenous injection of Evan's blue. The endometrium was dyed by Evan's blue and the mean points of response were observed on Pd 5. The expression of LIF mRNA and protein was detected by RT-PCR and immunohistochemistry respectively and analyzed statistically by image system. The results showed that the number of implantation sites in model group was remarkably less than in normal control group and TCM group. There was no significant difference between normal control group and TCM group. The expression of LIF mRNA and protein in model group was delayed. Bushenantai recipe could increase the expression of LIF mRNA and protein in endometria of mice with EID. It was suggested that Bushenantai recipe could improve embryo implantation of mice with EID by promoting the endometrial LIF expression and endometrial decidualization.

Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. Publishing Authors By Initials

M Zhang,Y Huang,G Zhu,G Huang,L Dong,J Zhang,

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Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 28

Page Numbers: 65-8

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 18

MONTH: Feb

YEAR: 2008

Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. Information

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LANGUAGE: eng

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AFFILIATION: Department of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China, mmzhang@tjh.tjmu.edu.cn.

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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